Monocytes are innate immune cells essential for host protection against malaria. Upon activation, monocytes function to help reduce parasite burden through phagocytosis, cytokine production, and antigen presentation. However, monocytes have also been implicated in the pathogenesis of severe disease through production of damaging inflammatory cytokines, resulting in systemic inflammation and vascular dysfunction. Understanding the molecular pathways influencing the balance between protection and pathology is critical. In this review, we discuss recent data regarding the role of monocytes in human malaria, including studies of innate sensing of the parasite, immunometabolism, and innate immune training. Knowledge gained from these studies may guide rational development of novel antimalarial therapies and inform vaccine development.

中文翻译：

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对疟疾的先天免疫-单核细胞的作用。

单核细胞是先天免疫细胞，对于宿主抵抗疟疾具有重要作用。激活后，单核细胞的功能是通过吞噬作用，细胞因子产生和抗原呈递来帮助减少寄生虫负担。然而，单核细胞还通过产生破坏性的炎性细胞因子而参与了严重疾病的发病机理，从而导致全身性炎症和血管功能障碍。了解影响保护与病理之间平衡的分子途径至关重要。在这篇综述中，我们讨论了有关单核细胞在人类疟疾中的作用的最新数据，包括对寄生虫的先天感知，免疫代谢和先天免疫训练的研究。从这些研究中获得的知识可以指导新型抗疟疾治疗方法的合理开发，并为疫苗开发提供信息。