The first enantioselective assembly of sandwich-shaped organo molecules has been achieved by conducting dual asymmetric Suzuki-Miyaura couplings and nine other reactions. This work also presents the first fully C-C anchored multi-layer 3D chirality with optically pure enantiomers. As confirmed by X-ray diffraction analysis that this chiral framework is featured by a unique C2-symmetry in which a nearly parallel fashion consisting of three layers: top, middle and bottom aromatic rings. Unlike the documented planar or axial chirality, the present chirality shows its top and bottom layers restrict each other from free rotation, i.e., this multi-layer 3D chirality would not exist if either top or bottom layer is removed. Nearly all multi-layered compounds showed strong luminescence of different colors under UV irradiation, and several randomly selected samples displayed aggregation-induced emission (AIE) properties. This work is believed to have broad impacts on chemical, medicinal and material sciences including optoelectronic materials in future.

中文翻译：

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多层 3D 手性的对映选择性组装

通过进行双重不对称铃木-宫浦偶联和其他九个反应，实现了三明治状有机分子的首次对映选择性组装。这项工作还提出了第一个具有光学纯对映体的完全 CC 锚定的多层 3D 手性。X射线衍射分析证实，该手性骨架具有独特的C2对称性，由上、中、下芳环三层组成，几乎平行。与记录的平面或轴向手性不同，本手性显示其顶层和底层相互限制自由旋转，即，如果顶层或底层被移除，则这种多层3D手性将不存在。几乎所有多层化合物在紫外线照射下都表现出不同颜色的强发光，并且一些随机选择的样品表现出聚集诱导发射（AIE）特性。这项工作被认为将对未来的化学、医学和材料科学（包括光电材料）产生广泛的影响。