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Men and Women Have an Equal Oropharyngeal and Anorectal Chlamydia trachomatis Bacterial Load: A Comparison of 3 Anatomic Sites
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2019-12-16 , DOI: 10.1093/infdis/jiz668
Juliën N A P Wijers 1, 2 , Nicole H T M Dukers-Muijrers 1, 2 , Geneviève A F S van Liere 1, 2 , Jeanne A M C Dirks 1 , Petra F G Wolffs 1 , Christian J P A Hoebe 1, 2
Affiliation  

Abstract
Background
The Chlamydia trachomatis bacterial load could have impact on transmission and sequelae. This is the first study providing comparison of C. trachomatis load at 3 anatomic sites estimated by cycle quantification (Cq) values.
Methods
Data from 7900 C. trachomatis-positive samples were included (2012–2018). Cq value was used as an inversely proportional measure for C. trachomatis load. Multivariable linear regression analyses assessed differences in mean Cq values.
Results
Vaginal swabs had the lowest Cq values (31.0) followed by urine (32.5), anorectal swabs (34.0), and oropharyngeal swabs (36.8) (P < .001). Men and women had similar oropharyngeal (36.4 vs 37.3; P = .13) and anorectal (34.2 vs 33.9; P = .19) Cq values. Men (32.2) and women (30.7) aged <25 years had lower urogenital Cq values than men (32.8) and women (31.9) aged ≥25 years (P < .001). HIV-positive patients had higher urogenital Cq values than HIV-negative patients (33.8 vs 32.6; P < .03).
Conclusions
Men and women have a similar C. trachomatis load at extragenital locations arguing for similar transmission potential and clinical relevance. Older patients and HIV-coinfected patients had lower C. trachomatis load, suggesting exposure to previous C. trachomatis infections potentially leading to partial immunity reducing load.


中文翻译:

男性和女性的口咽部和肛门直肠沙眼衣原体细菌负荷相同:3 个解剖部位的比较

摘要
背景
沙眼衣原体细菌负荷可能对传播和后遗症产生影响。这是第一项提供通过循环量化 (Cq) 值估计的 3 个解剖部位的沙眼衣原体负荷比较的研究。
方法
包括来自 7900个沙眼衣原体阳性样本的数据(2012-2018 年)。Cq 值被用作沙眼衣原体负荷的反比量度。多变量线性回归分析评估了平均 Cq 值的差异。
结果
阴道拭子的 Cq 值最低 (31.0),其次是尿液 (32.5)、肛门直肠拭子 (34.0) 和口咽拭子 (36.8) ( P < .001)。男性和女性的口咽(36.4 对 37.3;P = .13)和肛门直肠(34.2 对 33.9;P = .19)Cq 值相似。<25 岁的男性 (32.2) 和女性 (30.7) 的泌尿生殖器 Cq 值低于≥25 岁的男性 (32.8) 和女性 (31.9) ( P < .001)。HIV 阳性患者的泌尿生殖器 Cq 值高于 HIV 阴性患者(33.8 vs 32.6;P < .03)。
结论
男性和女性在生殖器外部位具有相似的沙眼衣原体负荷,认为具有相似的传播潜力和临床相关性。老年患者和 HIV 合并感染患者的沙眼衣原体负荷较低,这表明暴露于先前的沙眼衣原体感染可能导致部分免疫力降低负荷。
更新日期:2019-12-16
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