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Exploration of highly selective fluorogenic 'on-off' chemosensor for H2 PO4 - ions: ICT-based sensing and ATPase activity profiling.
Luminescence ( IF 2.9 ) Pub Date : 2019-12-16 , DOI: 10.1002/bio.3737
Yogesh B Wagh 1 , Kundan C Tayade 2 , Anil Kuwar 1 , Suban K Sahoo 3 , Mayank 4 , Narinder Singh 4 , Dipak S Dalal 1
Affiliation  

In this study, the recognition contour of Chemosensor 1 was investigated using semiaqueous methanol (XH , mole fraction = 0.31) for a range of anions and bioactive species. Host-receptor signalling based on the internal charge transfer mechanism for Chemosensor 1 was explored and reported. Structure of Chemosensor 1 and its plausible anion coordination based on hydrogen bonding is complemented with density functional theory. Consequently, we investigated the applicability of the synthesized probe in blood plasma, urine, tap water samples, and for monitoring of ATP in lysosomes by apyrase enzyme.

中文翻译:

探索用于H2 PO4-离子的高选择性荧光“开-关”化学传感器:基于ICT的传感和ATPase活性分析。

在这项研究中,化学传感器1的识别轮廓是使用半水甲醇(XH,摩尔分数= 0.31)对一系列阴离子和生物活性物质进行研究的。探索和报道了基于内部电荷转移机制的化学传感器1的宿主受体信号传导。密度泛函理论补充了化学传感器1的结构及其基于氢键的可能的阴离子配位。因此,我们调查了合成探针在血浆,尿液,自来水样品中的适用性,以及通过腺苷三磷酸酶监测溶酶体中ATP的适用性。
更新日期:2020-04-03
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