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Role of the PI3K/AKT pathway and PTEN in otitis media.
Experimental Cell Research ( IF 3.7 ) Pub Date : 2019-12-13 , DOI: 10.1016/j.yexcr.2019.111758
Hwan Ho Lee 1 , Anthony Chin 1 , Kwang Pak 1 , Stephen I Wasserman 1 , Arwa Kurabi 1 , Allen F Ryan 1
Affiliation  

Mucosal hyperplasia is common sequela of otitis media (OM), leading to the secretion of mucus and the recruitment of leukocytes. However, the pathogenic mechanisms underlying hyperplasia are not well defined. Here, we investigated the role of the AKT pathway in the development of middle mucosal hyperplasia using in vitro mucosal explants cultures and an in vivo rat model. The Akt inhibitor MK2206 treatment inhibited the growth of middle ear mucosal explants in a dose-dependent manner. In vivo, MK2206 also reduced mucosal hyperplasia. Unexpectedly, while PTEN is generally thought to act in opposition to AKT, the PTEN inhibitor BPV reduced mucosal explant growth in vitro. The results indicate that both AKT and PTEN are mediators of mucosal growth during OM, and could be potential therapeutic targets.

中文翻译:

PI3K / AKT途径和PTEN在中耳炎中的作用。

粘膜增生是中耳炎(OM)的常见后遗症,导致粘液分泌和白细胞募集。但是,增生的致病机制尚不明确。在这里,我们使用体外粘膜外植体培养和体内大鼠模型调查了AKT通路在中层粘膜增生发展中的作用。Akt抑制剂MK2206的治疗以剂量依赖性方式抑制中耳黏膜外植体的生长。在体内,MK2206还可以减少粘膜增生。出乎意料的是,尽管通常认为PTEN与AKT相反,但PTEN抑制剂BPV降低了体外黏膜外植体的生长。结果表明,AKT和PTEN都是OM期间黏膜生长的介质,并且可能是潜在的治疗靶标。
更新日期:2019-12-17
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