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Distribution of glycated haemoglobin and its determinants in Indian young adults.
Diabetes Research and Clinical Practice ( IF 5.1 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.diabres.2019.107982 Raghuram Nagarathna 1 , Navneet Kaur 2 , Akshay Anand 3 , Kanupriya Sharma 3 , Rima Dada 4 , Palukuru Sridhar 1 , Purnendu Sharma 1 , Amit Kumar Singh 1 , Suchitra Patil 1 , Hongasandra R Nagendra 1
Diabetes Research and Clinical Practice ( IF 5.1 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.diabres.2019.107982 Raghuram Nagarathna 1 , Navneet Kaur 2 , Akshay Anand 3 , Kanupriya Sharma 3 , Rima Dada 4 , Palukuru Sridhar 1 , Purnendu Sharma 1 , Amit Kumar Singh 1 , Suchitra Patil 1 , Hongasandra R Nagendra 1
Affiliation
AIM
The aim of the present study is to understand the distribution of A1c in four different age groups in young adults and its relation to other co-variants.
METHODS
The countrywide data was collected in 2017 in Individuals with high risk analysed by Indian Diabetes Risk Score (IDRS) and self-declared diabetics were identified after screening a sample of 240,968 individuals from rural (4 villages of about 500 adults each) and urban (4 census enumeration blocks of about 500 adults each) population spanning 65 districts of 29 states/UTs of Indian subcontinent. Blood tests and other detailed assessments were carried out on this selected group. This study presents the analysis of the A1c values of 2862 young adults (<35 years).
RESULTS
In the age group of 31-34 years, the proportion of Diabetes (22.36%) and Prediabetes (9.86%) was higher in comparison with younger age groups. Also, Diabetes (7.3%) and Prediabetes (22%) were highest among those who had parental history of DM in both parents as compared to those with Diabetes history in one parent [Diabetes (7.1%) or Prediabetes (19.0%)] and no Diabetes Parental History (Diabetes (7.3%) and Prediabetes (18.3%) cases. BMI was found to play a significant positive correlation with Diabetes and Prediabetes (p < 0.001) with range of A1c.
CONCLUSION
Age, BMI and parental history were found to be correlated with A1c levels in IDRS screened high-risk population. With increasing age, the proportion of Diabetics and Prediabetics also increased with positive correlation of age with A1c levels.
中文翻译：
糖化血红蛋白及其决定因素在印度年轻人中的分布。
目的本研究的目的是了解年轻人中四个不同年龄组中A1c的分布及其与其他协变量的关系。方法2017年通过印度糖尿病风险评分（IDRS）分析的高危人群中收集了全国性数据，并从农村（4个村庄，每个成年人约500名成人）和城市（分布在印度次大陆29个州/犹他州65个地区的4个人口普查列举区，每个区约500个成年人。在这个选定的人群中进行了血液检查和其他详细评估。这项研究提出了对2862名年轻成年人（<35岁）的A1c值的分析。结果在31-34岁年龄段中，糖尿病（22.36％）和糖尿病前期（9。86％）高于年轻年龄组。此外，与父母中有糖尿病史的人相比，父母中有糖尿病史的人中糖尿病（7.3％）和糖尿病前期者（22％）最高[糖尿病（7.1％）或糖尿病前期（19.0％）]和无糖尿病父母史（糖尿病（7.3％）和糖尿病前期（18.3％）病例。发现BMI与糖尿病和糖尿病前期（p <0.001）在A1c范围内呈显着正相关。结论发现年龄，BMI和父母史与IDRS筛查的高危人群的A1c水平相关；随着年龄的增长，糖尿病和糖尿病前期患者的比例也随着年龄与A1c水平的正相关而增加。发现BMI与A1c范围与糖尿病和糖尿病前期有显着正相关（p <0.001）。结论在IDRS筛查的高危人群中，年龄，BMI和父母史与A1c水平相关。随着年龄的增长，糖尿病患者和糖尿病前期患者的比例也随着年龄与A1c水平的正相关而增加。发现BMI与A1c范围与糖尿病和糖尿病前期有显着正相关（p <0.001）。结论在IDRS筛查的高危人群中，年龄，BMI和父母史与A1c水平相关。随着年龄的增长，糖尿病患者和糖尿病前期患者的比例也随着年龄与A1c水平的正相关而增加。
更新日期：2019-12-17
中文翻译：
糖化血红蛋白及其决定因素在印度年轻人中的分布。
目的本研究的目的是了解年轻人中四个不同年龄组中A1c的分布及其与其他协变量的关系。方法2017年通过印度糖尿病风险评分（IDRS）分析的高危人群中收集了全国性数据，并从农村（4个村庄，每个成年人约500名成人）和城市（分布在印度次大陆29个州/犹他州65个地区的4个人口普查列举区，每个区约500个成年人。在这个选定的人群中进行了血液检查和其他详细评估。这项研究提出了对2862名年轻成年人（<35岁）的A1c值的分析。结果在31-34岁年龄段中，糖尿病（22.36％）和糖尿病前期（9。86％）高于年轻年龄组。此外，与父母中有糖尿病史的人相比，父母中有糖尿病史的人中糖尿病（7.3％）和糖尿病前期者（22％）最高[糖尿病（7.1％）或糖尿病前期（19.0％）]和无糖尿病父母史（糖尿病（7.3％）和糖尿病前期（18.3％）病例。发现BMI与糖尿病和糖尿病前期（p <0.001）在A1c范围内呈显着正相关。结论发现年龄，BMI和父母史与IDRS筛查的高危人群的A1c水平相关；随着年龄的增长，糖尿病和糖尿病前期患者的比例也随着年龄与A1c水平的正相关而增加。发现BMI与A1c范围与糖尿病和糖尿病前期有显着正相关（p <0.001）。结论在IDRS筛查的高危人群中，年龄，BMI和父母史与A1c水平相关。随着年龄的增长，糖尿病患者和糖尿病前期患者的比例也随着年龄与A1c水平的正相关而增加。发现BMI与A1c范围与糖尿病和糖尿病前期有显着正相关（p <0.001）。结论在IDRS筛查的高危人群中，年龄，BMI和父母史与A1c水平相关。随着年龄的增长，糖尿病患者和糖尿病前期患者的比例也随着年龄与A1c水平的正相关而增加。
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