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Regioselective Hydroiodination of Alkynes by in situ‐Generated HI
Asian Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2020-01-07 , DOI: 10.1002/ajoc.201900677
Jiayan Li 1 , Ronibala Devi Laishram 1 , Jingchao Chen 1 , Dandan Xu 1 , Guangrui Shi 1 , Haiping Lv 1 , Ruifeng Fan 1 , Baomin Fan 1, 2
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An efficient and highly selective hydroiodination of alkynes has been reported. The reaction utilizes in situ‐generated HI from [Rh]‐complex, molecular hydrogen, and iodine under ambient temperature. The methodology provided the Markovnikov products exclusively from terminal alkynes, and predominately E‐isomers from the internal alkynes in good yields. The reaction could be performed on a gram‐scale with good yield.

中文翻译:

原位HI对炔烃的区域选择性加氢碘化

已经报道了炔烃的高效且高度选择性的加氢碘化。该反应在环境温度下利用[Rh]-络合物,分子氢和碘的原位生成的HI。该方法只提供末端炔烃的马尔科夫尼科夫产品,而主要提供内部炔烃的E-异构体,收率很高。该反应可以以克为单位进行,收率很高。
更新日期:2020-01-07
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