Single-cell RNA sequencing and single-nucleus RNA sequencing have recently provided the opportunity to investigate cellular and molecular aspects of neuro-immune interactions in the brain with unprecedented detail. Here, we highlight the major advances in human neuroimmunology reported this year based on these cutting-edge technologies. Here, Marco Colonna and Simone Brioschi highlight several key papers from 2019 that used single-cell and single-nucleus RNA sequencing to provide exciting insights into the neuro-immune interactions that occur in the healthy and diseased brain.

中文翻译：

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单细胞分辨率下人脑中的神经发炎和神经退行性变。

单细胞RNA测序和单核RNA测序最近提供了机会，以前所未有的细节研究大脑中神经免疫相互作用的细胞和分子方面。在这里，我们重点介绍了今年基于这些尖端技术报道的人类神经免疫学的重大进展。在这里，Marco Colonna和Simone Brioschi重点介绍了2019年的几篇重要论文，这些论文使用单细胞和单核RNA测序对健康和患病大脑中发生的神经免疫相互作用提供了令人兴奋的见解。