Overexpression of JUN by CAR T cells renders them resistant to exhaustion and improves tumour control in mouse models, including of solid tumours and of tumours with low levels of antigen expression.

中文翻译：

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克服CAR T细胞衰竭。

CAR T细胞对JUN的过表达使其具有抗力衰竭的能力，并改善了小鼠模型（包括实体瘤和抗原表达水平较低的肿瘤）的肿瘤控制。