Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

中文翻译：

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单胺氧化酶线粒体穿梭的多巴胺代谢激活电子传递链。

单胺氧化酶 (MAO) 代谢胞质多巴胺 (DA)，从而限制自动氧化，但也被认为会产生胞质过氧化氢 (H2O2)。我们表明，DA 的 MAO 代谢不会增加细胞溶质 H2O2，但会导致线粒体电子传递链 (ETC) 活性。这取决于 MAO 锚定到线粒体外膜并通过膜间空间穿梭电子以支持阶段性 DA 释放的生物能量需求。