Distance Disintegration Delineates the Brain Connectivity Failure of Alzheimer’s Disease,Neurobiology of Aging

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Distance Disintegration Delineates the Brain Connectivity Failure of Alzheimer’s Disease
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.neurobiolaging.2019.12.005
Víctor Costumero ₁ , Federico d'Oleire Uquillas ₂ , Ibai Diez ₃ , Magi Andorrà ₄ , Silvia Basaia ₅ , Elisenda Bueichekú ₆ , Laura Ortiz-Terán ₇ , Vicente Belloch ₈ , Joaquin Escudero ₉ , César Ávila ₁₀ , Jorge Sepulcre ₁₁

Affiliation

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Catalonia, Spain; Neuropsychology and Functional Neuroimaging Group, Department of basic Psychology, University Jaume I, Castellón, Valencian Community, Spain.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Neurotechnology Laboratory, Tecnalia Health Department, Basque Country, Spain.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center of Neuroimmunology, Department of Neurology, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Neuroimaging Research Unit Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Neuropsychology and Functional Neuroimaging Group, Department of basic Psychology, University Jaume I, Castellón, Valencian Community, Spain.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ERESA Medical Group, Valencia, Valencian community, Spain.
Department of Neurology, General Hospital of Valencia, Valencia, Valencian Community, Spain.
Neuropsychology and Functional Neuroimaging Group, Department of basic Psychology, University Jaume I, Castellón, Valencian Community, Spain.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

Alzheimer's disease (AD) is associated with brain network dysfunction. Network-based investigations of brain connectivity have mainly focused on alterations in the strength of connectivity; however, the network breakdown in AD spectrum is a complex scenario in which multiple pathways of connectivity are affected. To integrate connectivity changes that occur under AD-related conditions, here we developed a novel metric that computes the connectivity distance between cortical regions at the voxel level (or nodes). We studied 114 individuals with mild cognitive impairment, 24 with AD, and 27 healthy controls. Results showed that areas of the default mode network, salience network, and frontoparietal network display a remarkable network separation, or greater connectivity distances, from the rest of the brain. Furthermore, this greater connectivity distance was associated with lower global cognition. Overall, the investigation of AD-related changes in paths and distances of connectivity provides a novel framework for characterizing subjects with cognitive impairment; a framework that integrates the overall network topology changes of the brain and avoids biases toward unreferenced connectivity effects.

中文翻译：

距离瓦解描述了阿尔茨海默氏病的大脑连接故障

阿尔茨海默病（AD）与大脑网络功能障碍有关。基于网络的大脑连接研究主要集中在连接强度的变化上。然而，AD 频谱中的网络故障是一个复杂的场景，其中多个连接路径受到影响。为了整合 AD 相关条件下发生的连接变化，我们开发了一种新的度量，可以计算体素水平（或节点）的皮质区域之间的连接距离。我们研究了 114 名轻度认知障碍患者、24 名 AD 患者和 27 名健康对照者。结果表明，默认模式网络、显着性网络和额顶叶网络的区域与大脑的其他部分表现出显着的网络分离或更大的连接距离。此外，这种更大的连接距离与较低的整体认知有关。总体而言，对 AD 相关的连接路径和距离变化的研究为表征认知障碍受试者提供了一个新颖的框架；一个框架，整合了大脑的整体网络拓扑变化，并避免了对未参考连接效应的偏见。

更新日期：2020-04-01

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