BACKGROUND Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. This systematic review evaluated the effectiveness of psychological interventions for cancer-related fatigue in post-treatment cancer survivors. METHODS We searched relevant online databases and sources of grey literature. Randomised controlled trials (RCTs) evaluating psychological interventions in adult cancer patients after the completion of treatment, with fatigue as an outcome measure, were included. Two review authors extracted data independently from the selected studies and assessed the methodological quality using the Cochrane Collaboration Risk of Bias Tool. RESULTS Thirty-three psychological interventions were identified. The sample size of the included studies varied between 28 and 409, with 4525 participants overall. Twenty-three of the included studies reported a significant effect of the interventions on reducing fatigue in cancer survivors. Most interventions focused on psychoeducation, mindfulness, cognitive or behaviour therapy-oriented strategies. However, studies differed widely in terms of measurement tools used to assess fatigue, mode, duration and frequency of the intervention delivery. CONCLUSIONS This review showed some tentative support for psychological interventions for fatigue after cancer treatment. However, as the RCTs were heterogeneous in nature and the number of high-quality studies was limited, definitive conclusions are not yet possible. With the growing need for stage-specific research in cancer, this review sought to inform current practice and to summarise the existing evidence base of randomised controlled trials in the area. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration number: CRD42014015219.

中文翻译：

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心理干预对癌症幸存者疲劳的有效性：随机对照试验的系统评价。

背景技术疲劳是癌症患者中的常见症状，其可以持续超过治愈性治疗阶段。该系统评价评估了心理干预对治疗癌症后幸存者癌症相关疲劳的有效性。方法我们搜索了相关的在线数据库和灰色文献来源。包括随机对照试验（RCT），该试验评估了完成治疗后成人癌症患者的心理干预，并以疲劳作为结果指标。两位评价作者从所选研究中独立提取数据，并使用Cochrane协作偏倚风险工具评估了方法学质量。结果确定了33项心理干预措施。纳入研究的样本量在28到409个之间变化，总共有4525名参与者。纳入的研究中有23项报道了干预措施对减轻癌症幸存者疲劳的显著作用。大多数干预措施都集中在以心理教育，正念，认知或行为疗法为导向的策略上。但是，在用于评估疲劳，方式，持续时间和干预措施频率的测量工具方面，研究存在很大差异。结论本评价显示了对癌症治疗后疲劳的心理干预的初步支持。但是，由于RCT本质上是异质的，并且高质量研究的数量有限，因此尚不可能得出明确的结论。随着对癌症特定阶段研究的需求不断增长，本综述试图为当前的实践提供信息，并总结该地区随机对照试验的现有证据基础。