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STLV-1 as a model for studying HTLV-1 infection
Retrovirology ( IF 3.3 ) Pub Date : 2019-12-01 , DOI: 10.1186/s12977-019-0503-0
Brice Jégado 1 , Fatah Kashanchi 2 , Hélène Dutartre 1 , Renaud Mahieux 1
Affiliation  

Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As HTLV-1, STLV-1 is the etiological agent of ATL, while no case of TSP/HAM has been described. Given its similarities with HTLV-1, STLV-1 represents a unique tool used for performing clinical studies, vaccine studies as well as basic science.

中文翻译:

STLV-1 作为研究 HTLV-1 感染的模型

在人类中鉴定和分离 HTLV-1 几年后,发现了它的猿猴对应物 STLV-1。然后很明显STLV-1几乎存在于所有猿猴物种中。随后的分子流行病学研究表明,除了 HTLV-1 A 亚型外,所有人类亚型都具有猿猴同源性。作为 HTLV-1,STLV-1 是 ATL 的病原体,而尚未描述 TSP/HAM 的病例。鉴于其与 HTLV-1 的相似之处,STLV-1 代表了一种用于进行临床研究、疫苗研究以及基础科学的独特工具。
更新日期:2019-12-01
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