Obesity is the most common nutritional disorder worldwide and is associated with dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in obesity is low high density lipoprotein (HDL) cholesterol (HDL-C) levels. Moreover, the quality of HDL is also changed in the obese setting. However, there are still some disputes on the explanations for this phenomenon. There is increasing evidence that adipose tissue, as an energy storage tissue, participates in several metabolism activities, such as hormone secretion and cholesterol efflux. It can influence overall reverse cholesterol transport and plasma HDL-C level. In obesity individuals, the changes in morphology and function of adipose tissue affect plasma HDL-C levels and HDL function, thus, adipose tissue should be the main target for the treatment of HDL metabolism in obesity. In this review, we will summarize the cross-talk between adipocytes and HDL related to cardiovascular disease and focus on the new insights of the potential mechanism underlying obesity and HDL dysfunction.

中文翻译：

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脂肪细胞与高密度脂蛋白之间的相互作用：肥胖引起的血脂异常和动脉粥样硬化机制的新见解。

肥胖是全世界最常见的营养失调，与血脂异常和动脉粥样硬化性心血管疾病有关。肥胖症中血脂异常的标志是低高密度脂蛋白（HDL）胆固醇（HDL-C）水平。此外，在肥胖环境中，HDL的质量也会改变。但是，对于这种现象的解释仍然存在一些争议。越来越多的证据表明，作为能量存储组织的脂肪组织参与了几种新陈代谢活动，例如激素分泌和胆固醇外排。它可以影响总体胆固醇反向转运和血浆HDL-C水平。在肥胖个体中，脂肪组织的形态和功能变化会影响血浆HDL-C水平和HDL功能，因此，脂肪组织应成为肥胖症中HDL代谢治疗的主要目标。在这篇综述中，我们将总结与心血管疾病相关的脂肪细胞和HDL之间的相互影响，并着重于肥胖和HDL功能障碍的潜在机制的新见解。