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Association of adverse childhood experiences and neurodevelopmental disorders in people with fetal alcohol spectrum disorders (FASD) and non-FASD controls.
BMC Pediatrics ( IF 2.4 ) Pub Date : 2019-12-16 , DOI: 10.1186/s12887-019-1878-8
Cassondra Kambeitz 1 , Marilyn G Klug 2 , Jacob Greenmyer 1 , Svetlana Popova 3, 4, 5 , Larry Burd 1
Affiliation  

BACKGROUND Fetal alcohol spectrum disorder (FASD) is a highly prevalent lifelong disorder with high rates of comorbid neurodevelopmental disorders. Individuals with FASD are often exposed to abuse, neglect and foster home placements which have uncertain effects on the lifelong course of FASD. In this study we compare the prevalence of adverse childhood events (ACEs) and neurodevelopmental disorders in subjects with fetal alcohol spectrum disorders (FASD) and non-FASD controls. METHODS A cross-sectional chart review of patients referred to a regional developmental center was used to identify people with FASD and non-FASD controls. We recorded the number of ACEs and neurodevelopmental disorders in each patient's chart. The most common diagnoses were attention deficit hyperactivity disorder, comprehension deficits, sleep disorders, and cognitive impairments. T-tests and a regression equation were utilized to determine significant differences between the groups. RESULTS The review identified 203 subjects, 98 with FASD and 105 non-FASD controls. Group mean age was 8.6 years and 64.5% were male. People with FASD were more likely to have any ACEs (mean 5.3) with ACE scores 3.7 points higher than non-FASD controls (mean 1.69) (t = 11.29; p < .001). Increased ACEs were associated with increased rates of neurodevelopmental disorders for people with FASD (R = .179, p = .026) but not for non-FASD controls (R = .130, p = .094). CONCLUSIONS Both FASD and subsequent exposure to ACEs are associated with increased risk for development of comorbid neurodevelopmental disorders. Prevention of ACEs during childhood may decrease risk for development of comorbid neurodevelopmental disorders.

中文翻译:

胎儿酒精性频谱障碍(FASD)和非FASD对照者的不良童年经历与神经发育障碍的关联。

背景技术胎儿酒精谱疾病(FASD)是一种高度流行的终身疾病,具有较高的合并症神经发育障碍。患有FASD的人经常遭受虐待,疏忽和寄养家庭安置,这对FASD的整个生命周期产生不确定的影响。在这项研究中,我们比较了胎儿酒精性谱系障碍(FASD)和非FASD对照受试者的不良儿童期事件(ACE)和神经发育障碍的患病率。方法采用横断面图检查方法将患者转诊至区域发展中心,以鉴定患有FASD和非FASD对照的患者。我们在每位患者的图表中记录了ACEs和神经发育障碍的数量。最常见的诊断是注意缺陷多动障碍,理解缺陷,睡眠障碍,和认知障碍。利用T检验和回归方程确定两组之间的显着差异。结果该评价确定了203名受试者,其中98名患有FASD,105名非FASD对照。小组平均年龄为8.6岁,男性为64.5%。患有FASD的人更有可能拥有ACE得分(平均5.3),而ACE得分比非FASD对照(平均1.69)高3.7分(t = 11.29; p <.001)。ACE的增加与FASD患者的神经发育障碍发生率增加相关(R = .179,p = .026),而非FASD对照则与否(R = .130,p = .094)。结论FASD和随后暴露于ACEs都与合并神经发育障碍的发展风险增加有关。
更新日期:2019-12-16
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