BACKGROUND Helicobacter pylori infection is known to alter growth-related hormones and affect growth in young children. However, it is still unknown whether maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and whether this can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. METHODS In this prospective cohort study, we recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined as > 12 U/ml of anti-H. pylori IgG in maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA. The growth of the included neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. RESULTS Of the 106 enrolled women, 25 (23.6%) were H. pylori-seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p = 0.04) and lower cord blood levels of IGF-1 (< 35 ng/ml, 70.0% vs. 40.7%, p = 0.02) and IGFBP-3 (< 1120 ng/ml, 100.0% vs. 76.3%, p = 0.02) compared with the seronegative women. No significant impacts on birth weight, childhood growth and cognitive development were found to be correlated with maternal H. pylori seropositivity during pregnancy. CONCLUSIONS Maternal H. pylori infection during pregnancy was more likely to lead to the development of GH, but was not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for mothers with H. pylori infection.

中文翻译：

---

孕妇幽门螺杆菌血清阳性与妊娠高血压有关，但与儿童早期的胎儿生长和发育无关。

背景技术已知幽门螺杆菌感染会改变与生长相关的激素并影响幼儿的生长。但是，尚不清楚产妇幽门螺杆菌感染是否会影响脐带血生长相关激素的水平，是否可以预测子宫内生长受限以及儿童身体和神经发育不良。这项研究旨在检查孕妇幽门螺杆菌感染与妊娠相关不良事件，胎儿生长和儿童早期发育之间的关联。方法在这项前瞻性队列研究中，我们招募了从2014年1月至2015年1月没有重大医学疾病的单身孕妇。幽门螺杆菌的血清阳性率定义为抗H≥12 U / ml。母体血清中的幽门螺杆菌IgG。记录了该人群的人口统计学数据和与妊娠有关的医学问题。使用ELISA测定胰岛素样生长因子1（IGF-1），胰岛素样生长因子结合蛋白3（IGFBP-3），胰岛素和生长素释放肽的脐带血水平。每年对所纳入新生儿的生长情况进行长达3年的监测，并使用出生后3年的婴幼儿综合发育量表（CDIIT）测试评估认知能力。结果在106名登记的女性中，有25名（23.6％）的幽门螺杆菌血清阳性。孕妇幽门螺杆菌血清阳性与发生妊娠高血压（GH）的较高风险（12％比1.2％，p = 0.04）和较低的IGF-1脐血水平（<35 ng / ml，70.0％vs.）有关。 40.7％，p = 0.02）和IGFBP-3（<1120 ng / ml，100.0％对76.3％，p = 0。02）与血清阴性的女性相比。没有发现对出生体重，儿童生长和认知发育的显着影响与孕期孕妇幽门螺杆菌血清阳性有关。结论孕期孕妇幽门螺杆菌感染更可能导致GH的发生，但与胎儿和儿童的生长发育无关。除了密切监测高血压外，对于患有幽门螺杆菌感染的母亲，还可考虑根除幽门螺杆菌。但与胎儿和儿童的生长发育无关。除了密切监测高血压外，对于患有幽门螺杆菌感染的母亲，还可考虑根除幽门螺杆菌。但与胎儿和儿童的生长发育无关。除了密切监测高血压外，对于患有幽门螺杆菌感染的母亲，还可考虑根除幽门螺杆菌。