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The concentration of resistin in perivascular adipose tissue after CABG and postoperative atrial fibrillation.
BMC Cardiovascular Disorders ( IF 2.1 ) Pub Date : 2019-12-16 , DOI: 10.1186/s12872-019-1254-5 Maciej Rachwalik 1 , Marta Obremska 1, 2 , Dorota Zyśko 3 , Małgorzata Matusiewicz 4 , Krzysztof Ściborski 5 , Marek Jasiński 1
BMC Cardiovascular Disorders ( IF 2.1 ) Pub Date : 2019-12-16 , DOI: 10.1186/s12872-019-1254-5 Maciej Rachwalik 1 , Marta Obremska 1, 2 , Dorota Zyśko 3 , Małgorzata Matusiewicz 4 , Krzysztof Ściborski 5 , Marek Jasiński 1
Affiliation
BACKGROUND
Postoperative atrial fibrillation occurs in up to 30% of patients after coronary artery bypass graft (CABG) and its cause is unknown. The aim of the study was to evaluate whether concentration of resistin in surrounding coronary artery perivascular adipose tissue (PVAT) is related to postoperative atrial fibrillation occurrence.
METHODS
A total number of 46 patients (35 male, 11 female; median age 66.5) were qualified for elective CABG. Medical history, laboratory test results and echocardiographic parameters were noted. Patients were monitored up to 3 days after CABG and then were divided into groups with and without postoperative atrial fibrillation occurrence. Fragments of PVAT were collected intra-operatively: near the left anterior descending artery and main left coronary artery. The concentration of resistin was determined by Human Resistin Quantikine ELISA Kit and expressed as ng/g. A multivariate stepwise logistic regression analysis was performed to find variables related to postoperative atrial fibrillation occurrence.
RESULTS
Postoperative atrial fibrillation occurred in 14 (30.4%) patients. The patients with and without postoperative atrial fibrillation were similar in age, gender, epicardial adipose tissue thickness and laboratory parameters. The concentration of resistin in PVAT near the left main coronary artery was significantly higher in patients with postoperative atrial fibrillation than in those without the complication (P = 0.03). In the multivariate stepwise logistic regression analysis the concentration of resistin above cut-off point 54 ng/g in PVAT near left main coronary artery was independently related to postoperative atrial fibrillation occurrence (OR: 7.7; 95% CI:1.4-42.2 p = 0.02).
CONCLUSIONS
The higher concentrations of resistin in PVAT near the left main coronary artery which is located close to the left atrium are associated with postoperative atrial fibrillation.
中文翻译:
CABG和术后房颤后血管周围脂肪组织中抵抗素的浓度。
背景技术冠状动脉搭桥术(CABG)后,多达30%的患者发生房颤。其原因尚不清楚。该研究的目的是评估冠状动脉周围血管脂肪组织(PVAT)周围的抵抗素浓度是否与术后房颤发生有关。方法共有46例患者(男35例,女11例;中位年龄66.5)符合选择性CABG的资格。记录病史,实验室检查结果和超声心动图参数。在CABG后最多3天对患者进行监测,然后将其分为有无术后房颤发生的组。术中收集PVAT片段:在左前降支动脉和左主冠状动脉附近。通过人类抵抗素Quantikine ELISA试剂盒测定抵抗素的浓度,并以ng / g表示。进行了多元逐步逻辑回归分析,以发现与术后房颤发生有关的变量。结果术后房颤发生在14例患者中(30.4%)。有和没有术后房颤的患者在年龄,性别,心外膜脂肪组织厚度和实验室参数方面相似。房颤患者术后左主冠状动脉附近PVAT的抵抗素浓度显着高于无并发症的患者(P = 0.03)。在多元逐步Logistic回归分析中,左主冠状动脉附近PVAT中截止点以上54 ng / g的抵抗素浓度与术后房颤发生独立相关(OR:7.7; 95%CI:1.4-42.2 p = 0.02 )。结论靠近左心房的左主冠状动脉附近的PVAT中较高的抵抗素浓度与术后房颤有关。
更新日期:2019-12-16
中文翻译:
CABG和术后房颤后血管周围脂肪组织中抵抗素的浓度。
背景技术冠状动脉搭桥术(CABG)后,多达30%的患者发生房颤。其原因尚不清楚。该研究的目的是评估冠状动脉周围血管脂肪组织(PVAT)周围的抵抗素浓度是否与术后房颤发生有关。方法共有46例患者(男35例,女11例;中位年龄66.5)符合选择性CABG的资格。记录病史,实验室检查结果和超声心动图参数。在CABG后最多3天对患者进行监测,然后将其分为有无术后房颤发生的组。术中收集PVAT片段:在左前降支动脉和左主冠状动脉附近。通过人类抵抗素Quantikine ELISA试剂盒测定抵抗素的浓度,并以ng / g表示。进行了多元逐步逻辑回归分析,以发现与术后房颤发生有关的变量。结果术后房颤发生在14例患者中(30.4%)。有和没有术后房颤的患者在年龄,性别,心外膜脂肪组织厚度和实验室参数方面相似。房颤患者术后左主冠状动脉附近PVAT的抵抗素浓度显着高于无并发症的患者(P = 0.03)。在多元逐步Logistic回归分析中,左主冠状动脉附近PVAT中截止点以上54 ng / g的抵抗素浓度与术后房颤发生独立相关(OR:7.7; 95%CI:1.4-42.2 p = 0.02 )。结论靠近左心房的左主冠状动脉附近的PVAT中较高的抵抗素浓度与术后房颤有关。