To investigate the association between serum amyloid A (SAA) protein and the clinical features of acute anterior uveitis (AAU), and to evaluate the disease activity and treatment effect in relation to SAA levels. AAU patients and healthy individuals were recruited from October 2016 to August 2017 at the Department of Uveitis, in the Eye Hospital of Wenzhou Medical University. Related demographic, clinical characteristics, and therapeutic data were analyzed. One hundred and eight AAU patients and 18 healthy controls were included in this study. Serum SAA levels in AAU patients were significantly higher than those of healthy controls (p all < 0.0001). Significantly higher SAA levels were found in AS+AAU patients than those in AS−AAU patients (p < 0.05). SAA levels were also significantly higher in patients with HLA-B27+AAU compared with those with HLA-B27−AAU (p < 0.05). Furthermore, in each of the AAU subgroups, higher SAA levels were observed in the active state than those in the inactive state (p all < 0.05). In addition, SAA levels were positively correlated to anterior chamber cell counts (r = 0.492, p < 0.0001). ROC curve analysis revealed that SAA had an AUC value of 0.727 for detecting active inflammation (Youden’s index = 0.38). SAA decreased with effective treatments (p = 0.0002). Serum levels of SAA were elevated in AAU patients. The increased levels of SAA were correlated with AS and HLA-B27 status. SAA levels were also positively correlated to disease activity and decreased with effective treatments. These findings suggest that SAA is associated with AAU, with a potential role in monitoring inflammatory processes and assessing the efficacy of therapy.

中文翻译：

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急性前葡萄膜炎患者血清淀粉样蛋白A水平、临床表现、治疗及疾病活动度的相关性

探讨血清淀粉样蛋白A (SAA) 蛋白与急性前葡萄膜炎(AAU) 临床特征的关系，并评估与SAA 水平相关的疾病活动性和治疗效果。AAU 患者和健康个体于 2016 年 10 月至 2017 年 8 月在温州医科大学眼科医院葡萄膜炎科招募。分析了相关的人口统计学、临床特征和治疗数据。本研究包括 108 名 AAU 患者和 18 名健康对照。AAU 患者的血清 SAA 水平显着高于健康对照组（p 均 < 0.0001）。AS+AAU 患者的 SAA 水平显着高于 AS-AAU 患者（p < 0.05）。与 HLA-B27-AAU 患者相比，HLA-B27+AAU 患者的 SAA 水平也显着升高（p < 0.05）。此外，在每个 AAU 亚组中，活动状态下的 SAA 水平高于非活动状态下的 SAA 水平（p 均 < 0.05）。此外，SAA 水平与前房细胞计数呈正相关（r = 0.492，p < 0.0001）。ROC 曲线分析显示，SAA 检测活动性炎症的 AUC 值为 0.727（约登指数 = 0.38）。SAA 随有效治疗而降低（p = 0.0002）。AAU 患者的血清 SAA 水平升高。SAA 水平升高与 AS 和 HLA-B27 状态相关。SAA 水平也与疾病活动呈正相关，并随着有效治疗而降低。这些发现表明 SAA 与 AAU 相关，