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Effect of BIN1 on cardiac dysfunction and malignant arrhythmias.
Acta Physiologica ( IF 6.3 ) Pub Date : 2019-12-13 , DOI: 10.1111/apha.13429
Xiao-Xin Jiang 1 , Yan-Rong Zhu 1 , Hong-Ming Liu 2 , Shao-Liang Chen 1 , Dai-Min Zhang 1
Affiliation  

Heart failure (HF) is the end-stage syndrome for most cardiac diseases, and the 5-year morbidity and mortality of HF remain high. Malignant arrhythmia is the main cause of sudden death in the progression of HF. Recently, bridging integrator 1 (BIN1) was discovered as a regulator of transverse tubule function and calcium signalling in cardiomyocytes. BIN1 downregulation is linked to abnormal cardiac contraction, and it increases the possibility of malignant arrhythmias preceding HF. Because of the detectability of cardiac BIN1 in peripheral blood, BIN1 may serve as a predictor of HF and may be useful in therapy development. However, the mechanism of BIN1 downregulation in HF and how BIN1 regulates normal cardiac function under physiological conditions remain unclear. In this review, recent progress in the biological studies of BIN1-related cardiomyocytes and the effect of cardiac dysfunction and malignant arrhythmia will be discussed.

中文翻译:

BIN1对心脏功能障碍和恶性心律失常的影响。

心力衰竭(HF)是大多数心脏病的终末期综合征,HF的5年发病率和死亡率仍然很高。恶性心律失常是心衰进展中猝死的主要原因。最近,桥接整合子1(BIN1)被发现作为心肌细胞中横向小管功能和钙信号传导的调节剂。BIN1的下调与异常的心脏收缩有关,它增加了HF之前发生恶性心律失常的可能性。由于在外周血中可检测到心脏BIN1,因此BIN1可以作为HF的预测因子,可能对治疗的发展很有用。但是,尚不清楚BIN1在HF中下调的机制以及BIN1在生理条件下如何调节正常的心脏功能。在这篇评论中,
更新日期:2019-12-27
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