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Impact of Standing Speed on the Peripheral and Central Hemodynamic Response to Orthostasis
Hypertension ( IF 8.3 ) Pub Date : 2020-02-01 , DOI: 10.1161/hypertensionaha.119.14040
John D O'Connor 1 , Matthew D L O'Connell 2 , Hugh Nolan 1 , Louise Newman 1 , Silvin P Knight 1 , Rose Anne Kenny 1
Affiliation  

Supplemental Digital Content is available in the text. Assessment of the cerebrovascular and cardiovascular response to standing has prognostic value for a range of outcomes in the older adult population. Studies generally attempt to control for standing speed differences by asking participants to stand in a specified time but little is known about the range of transition times observed. This study aimed to characterize how standing speed associates with cardiovascular and cerebrovascular measures following transition from supine to standing. Continuous cerebral oxygenation, heart rate, systolic and diastolic blood pressure were monitored for 3 minutes after transitioning from supine to standing. An algorithm was used to calculate the time taken to transition from existing Finometer data (from the height correction unit). Linear mixed-effects models were used to assess the influence of transition time on each of the signals while adjusting for covariates. Transition time ranged from 2 to 27 s with 17% of participants taking >10 s to stand. Faster transition was associated with a more extreme decrease 10 s after standing but improved recovery at 20 s for cerebral oxygenation and blood pressure. Standing faster was associated with an elevated heart rate on initiation of stand and a quicker recovery 10 to 20 s after standing. The speed of transitioning from supine to standing position is associated with cardiovascular and cerebrovascular response in the early period after standing (<40 s). Care should be taken in the interpretation of findings which may be confounded by standing speed and statistical adjustment for standing time should be applied where appropriate.

中文翻译:

站立速度对外周和中枢血流动力学响应的影响

补充数字内容在文本中可用。评估对站立的脑血管和心血管反应对老年人群的一系列结果具有预后价值。研究通常试图通过要求参与者在指定时间站立来控制站立速度差异,但对观察到的过渡时间范围知之甚少。本研究旨在描述从仰卧过渡到站立后站立速度如何与心脑血管测量相关。在从仰卧过渡到站立后,连续监测脑氧合、心率、收缩压和舒张压 3 分钟。一种算法用于计算从现有 Finometer 数据(来自高度校正单元)过渡所需的时间。线性混合效应模型用于评估过渡时间对每个信号的影响,同时调整协变量。转换时间从 2 秒到 27 秒不等,17% 的参与者站立时间超过 10 秒。更快的转变与站立 10 秒后更极端的下降有关,但在 20 秒后脑氧合和血压的恢复得到改善。站立更快与开始站立时心率升高以及站立后 10 至 20 秒恢复更快有关。从仰卧位过渡到站立位的速度与站立后早期(<40 s)的心脑血管反应有关。
更新日期:2020-02-01
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