Background

To compare outcomes of patients with arterially hyperenhancing intrahepatic cholangiocarcinomas (ICC) and arterially hypoenhancing ICCs after partial hepatectomy in a cohort with an analysis of prognostic factors.

Methods

From June 2009 to October 2011, a prospective cohort of 68 patients with single resectable ICCs (≤5 cm in diameter) underwent gadolinium contrast–enhanced dynamic-phase magnetic resonance imaging and were treated with partial hepatectomy. Patients were divided into those with arterially hyperenhancing ICCs (n = 28) or arterially hypoenhancing ICCs (n = 40). Clinic-radiologic-pathologic results and survival of these patients were compared and statistically analyzed.

Results

The median overall survival (OS) time was significantly longer in the arterially hyperenhancing ICCs (56.8 vs. 37.0 months) (p = 0.044). At pathologic evaluation, arterially hyperenhancing ICCs showed significantly higher microvessel count (MVC) than arterially hypoenhancing ICCs (106.2 ± 47.5 vs. 46.9 ± 21.6/mm², p = 0.001). Arterial enhancement of ICCs was found to be an independent prognostic factor for longer survival.

Conclusion

The presence of arterially hyperenhancing ICCs is related to higher MVC and exhibit a better OS time than arterially hypoenhancing ICCs after partial hepatectomy.

中文翻译：

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小肝内胆管癌的动脉过度增强与微血管计数和患者存活率相关。

背景

本研究旨在比较一个队列中动脉高增强性肝内胆管癌 (ICC) 和动脉性低增强性 ICCs 患者在部分肝切除术后的结果，并分析预后因素。

方法

从 2009 年 6 月到 2011 年 10 月，一个由 68 名具有单一可切除 ICC（直径 ≤ 5 cm）的患者组成的前瞻性队列接受了钆对比增强动态相位磁共振成像，并接受了部分肝切除术。患者分为动脉高增强 ICC（n = 28）或动脉低增强 ICC（n = 40）。比较和统计分析这些患者的临床-放射-病理结果和存活率。

结果

动脉高强化 ICC 的中位总生存 (OS) 时间显着更长（56.8个月与37.0 个月）（p  = 0.044）。在病理评估中，动脉高增强 ICC 显示出显着高于动脉低增强 ICC 的微血管计数 (MVC)（106.2 ± 47.5 vs. 46.9 ± 21.6/mm ²，p  = 0.001）。发现 ICC 的动脉增强是延长生存期的独立预后因素。

结论

在部分肝切除术后，动脉高增强 ICC 的存在与较高的 MVC 相关，并且比动脉低增强 ICC 显示出更好的 OS 时间。