Several research groups around the world have studied diverse aspects of energy metabolism in arthropod disease vectors, with the aim of discovering potential control targets. As in all oviparous organisms, arthropod embryonic development is characterized by the mobilization of maternally-derived metabolites for the formation of new tissues and organs. Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase described as an important regulator of metabolism and development in a wide range of organisms. GSK-3 was first identified based on its action upon glycogen synthase, a central enzyme in glycogen biosynthesis. Currently, it is recognized as a key component of multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, cell migration, and immune response. The present review will describe the current knowledge on GSK-3 activation and its role in morphogenesis and embryonic metabolism in arthropods. Altogether, the information discussed here can spark new approaches and strategies for further studies, enhancing our understanding of these important arthropod vectors and strengthening the resources in the search for novel control methods.

中文翻译：

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GSK-3在节肢动物的形态发生和胚胎发育代谢中的标志。

世界各地的几个研究小组已经研究了节肢动物疾病载体中能量代谢的各个方面，以期发现潜在的控制目标。像在所有卵生生物中一样，节肢动物的胚胎发育的特征是动员了母体来源的代谢产物以形成新的组织和器官。糖原合酶激酶3（GSK-3）是一种丝氨酸-苏氨酸激酶，被描述为多种生物体内新陈代谢和发育的重要调节剂。GSK-3首先基于其对糖原合酶（糖原生物合成中的核心酶）的作用进行鉴定。目前，它被认为是多种细胞过程的关键组成部分，例如葡萄糖代谢，细胞凋亡，细胞增殖，转录，细胞迁移和免疫反应。本综述将描述有关GSK-3激活及其在节肢动物的形态发生和胚胎代谢中的作用的最新知识。总之，这里讨论的信息可以激发进一步研究的新方法和策略，加深我们对这些重要节肢动物媒介的理解，并在寻找新的控制方法时加强资源。