Maintaining the ability to arrange thoughts and actions in an appropriate serial order is crucial for complex behavior. We aimed to investigate age differences in the fronto-striato-parietal network underlying serial ordering using functional magnetic resonance imaging. We exposed 25 young and 27 older healthy adults to a digit ordering task, where they had to reorder and recall sequential digits or simply to recall them. We detected a network comprising of the lateral and medial prefrontal, posterior parietal, and striatal regions. In young adults, the prefrontal and parietal regions were more activated and more strongly connected with the supplementary motor area for "reorder & recall" than "pure recall" trials (psychophysiological interaction, PPI). In older adults, the prefrontal and parietal activations were elevated, but the PPI was attenuated. Individual adults who had a stronger PPI performed more accurately in "reorder & recall" trials. The decreased PPI appeared to be compensated by increased physiological correlations between the prefrontal/parietal cortex and the striatum, and by that between the striatum and the supplementary motor area.

中文翻译：

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序列排序基础的额-纹状体-顶叶网络的年龄差异

保持以适当的顺序排列思想和行动的能力对于复杂行为至关重要。我们的目的是使用功能性磁共振成像研究基于序列排序的额-纹状体-顶叶网络的年龄差异。我们让 25 名年轻健康成人和 27 名年长健康成年人接受了数字排序任务，他们必须重新排序和回忆连续的数字，或者只是回忆它们。我们检测到一个由外侧和内侧前额叶、后顶叶和纹状体区域组成的网络。在年轻人中，与“纯回忆”试验（心理生理相互作用，PPI）相比，“重新排序和回忆”的前额叶和顶叶区域更活跃，与辅助运动区域的联系更紧密。在老年人中，前额叶和顶叶激活升高，但 PPI 有所减弱。具有更强 PPI 的个体成年人在“重新排序和回忆”试验中表现得更准确。降低的 PPI 似乎被前额叶/顶叶皮层与纹状体之间以及纹状体与辅助运动区域之间的生理相关性增加所补偿。