Each year over 200 million malaria infections occur, with over 400 000 associated deaths. Vaccines formed with attenuated whole parasites can induce protective memory CD8 T cell responses against liver-stage malaria; however, widespread administration of such vaccines is logistically challenging. Recent scientific findings are delineating how protective memory CD8 T cell populations are primed and maintained and how such cells mediate immunity to liver-stage malaria. Memory CD8 T cell anatomic localization and expression of transcription factors, homing receptors, and signaling molecules appear to play integral roles in protective immunity to liver-stage malaria. Further investigation of how such factors contribute to optimal protective memory CD8 T cell generation and maintenance in humans will inform efforts for improved vaccines.

中文翻译：

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您不应该通过：肝期疟疾中的记忆CD8 T细胞。

每年发生2亿多例疟疾感染，并造成40万多例相关死亡。整个寄生虫减毒形成的疫苗可以诱导针对肝脏阶段性疟疾的保护性记忆CD8 T细胞反应。然而，这种疫苗的广泛施用在后勤上具有挑战性。最近的科学发现描述了保护性记忆CD8 T细胞群体是如何引发和维持的，以及这些细胞如何介导对肝阶段疟疾的免疫力。记忆CD8 T细胞的解剖学定位以及转录因子，归巢受体和信号传导分子的表达似乎在保护肝阶段性疟疾的免疫中起着不可或缺的作用。进一步研究这些因素如何促进人类最佳的保护性记忆CD8 T细胞的产生和维持，将为改进疫苗的努力提供信息。