Monitoring of human serum albumin (HSA) in a point-of-care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, a dual-state emissive chalcone probe having the feature of aggregation-induced emission was designed and synthesized. The concentration of HSA can be evaluated by the ratios of emission from probes in aggregated and monomeric state, which gives a visually discernible red-to-green color change. A simple, portable paper-based analytical device have been fabricated by integration of the recognition probe in the detection pad and employed for HSA test using the whole blood samples. This paper-based assay shows the analytical capability comparable to the standard testing methods but is in a point-of-care fashion, providing a promising tool for at-home HSA detection and HSA-related disease diagnosis.

中文翻译：

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基于纸的比例荧光分析设备，用于人类血清白蛋白的即时检测。

急需以即时护理的方式监测人血清白蛋白（HSA），特别是对于年老或慢性病患者。在此，设计并合成了具有聚集诱导发射特征的双态发射查耳酮探针。HSA的浓度可以通过探针在聚集态和单体态下的发射比进行评估，从而可以从视觉上辨别出红色到绿色的颜色变化。通过将识别探针集成到检测垫中，可以制造出一种简单的，基于纸张的便携式分析设备，该设备可用于使用全血样本进行HSA测试。这种基于纸张的测定法显示了与标准测试方法相当的分析能力，但采用即时护理的方式，为在家中进行HSA检测和与HSA相关的疾病诊断提供了有希望的工具。