Cellulose-derived nanographene oxide (nGO)-type carbon dot reinforced porous scaffolds of poly(ε-caprolactone) (PCL) were developed as templates from high internal phase emulsions (HIPE). The mechanical strength, structural integrity, and reusability of the scaffolds were enhanced via in situ cross-linking. An oil-in-oil (o/o) HIPE of ε-caprolactone monomer (CL) was made for this purpose, and the ring-opening polymerization of a continuous phase comprised of CL, catalyst (Sn(Oct)2), and cross-linker (bis(caprolactone-4-yl)) (BCY) was carried out. The functionalization of scaffolds with nGO was assessed along with its role as an effective Pickering stabilizer of the HIPEs. The pore size and porosity of the scaffolds were governed by HIPE morphology, which in turn was controlled by the amount of nGO and the volume fraction of the dispersed phase. The nGO-functionalized scaffolds of cross-linked PCL thus prepared were characterized for their morphological structure, mechanical strength, and oil sorption capacity. Enhanced oil adsorption of nGO-functionalized scaffolds proved them to be of higher potency compared to those made of neat PCL. Superior compressive strength and reusability of scaffolds for oil adsorption up to 40 times while maintaining the structural integrity for ≥25 sorption-desorption cycles added extra value to such scaffolds. The scaffolds also had excellent cell viability as evaluated by MG63 osteoblast-like cells and some bioactivity in the form of calcium phosphate mineralization on the surface of the scaffolds.

中文翻译：

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高内相乳液模板交联聚（ε-己内酯）纤维素衍生的纳米氧化石墨烯增强大孔支架。

以高内相乳液（HIPE）为模板，开发了纤维素衍生的纳米氧化烯（nGO）型碳点增强多孔聚（ε-己内酯）（PCL）多孔支架。支架的机械强度，结构完整性和可重复使用性通过原位交联得到增强。为此目的，制备了ε-己内酯单体（CL）的油包油（o / o）HIPE，并且连续相的开环聚合由CL，催化剂（Sn（Oct）2）和进行交联剂（双（己内酯-4-基）（BCY）。评估了具有nGO的支架的功能性，以及其作为HIPEs的有效Pickering稳定剂的作用。支架的孔径和孔隙率由HIPE形态控制，而HIPE形态又由nGO的量和分散相的体积分数控制。如此制备的交联PCL的nGO官能化支架被表征为它们的形态结构，机械强度和吸油能力。与纯PCL制成的支架相比，nGO官能化的支架对油的吸附增强，证明它们具有更高的效能。支架具有出色的抗压强度和可重复使用性，可吸附多达40次油，同时在≥25个吸附-解吸循环中保持结构完整性，为此类支架增添了额外价值。如通过MG63成骨细胞样细胞所评估，该支架还具有优异的细胞生存力，并且在支架表面上以磷酸钙矿化的形式具有一些生物活性。和吸油量。与纯PCL制成的支架相比，nGO官能化的支架对油的吸附增强，证明它们具有更高的效能。支架具有出色的抗压强度和可重复使用性，可吸附多达40次油，同时在≥25个吸附-解吸循环中保持结构完整性，为此类支架增添了额外价值。如通过MG63成骨细胞样细胞所评估的，该支架还具有优异的细胞生存力，并且在支架表面上以磷酸钙矿化的形式具有一些生物活性。和吸油量。与纯PCL制成的支架相比，nGO官能化的支架对油的吸附增强，证明它们具有更高的效能。支架具有出色的抗压强度和可重复使用性，可吸附多达40次油，同时在≥25个吸附-解吸循环中保持结构完整性，为此类支架增添了额外价值。如通过MG63成骨细胞样细胞所评估，该支架还具有优异的细胞生存力，并且在支架表面上以磷酸钙矿化的形式具有一些生物活性。支架具有出色的抗压强度和可重复使用性，可吸附多达40次油，同时在≥25个吸附-解吸循环中保持结构完整性，为此类支架增添了额外价值。如通过MG63成骨细胞样细胞所评估的，该支架还具有优异的细胞生存力，并且在支架表面上以磷酸钙矿化的形式具有一些生物活性。支架具有出色的抗压强度和可重复使用性，可吸附多达40次油，同时保持结构完整性（≥25个吸附-解吸循环），为此类支架增添了额外价值。如通过MG63成骨细胞样细胞所评估，该支架还具有优异的细胞生存力，并且在支架表面上以磷酸钙矿化的形式具有一些生物活性。