Background Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. Methods Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. Results Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93–142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. Conclusions We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.

中文翻译：

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孕早期全氟烷基物质母体血清水平及子代出生体重

背景 全氟烷基物质 (PFAS) 分布广泛、具有生物累积性和持久性，并显示出胎盘转移。新兴研究表明产前暴露与低出生体重之间存在关联。本研究的目的是在瑞典环境、纵向、母亲和儿童、哮喘和过敏 (SELMA) 研究中评估孕早期 PFAS 暴露与出生体重 (BW) 之间的关联，并检查女孩和男孩之间的关联是否不同。方法 分析了母体血清（中位数：妊娠 10 周）中的 8 种 PFAS。在 1533 名婴儿中评估了产前 PFAS 暴露与出生结果与 BW、胎龄 BW 和小于胎龄 (SGA) 的出生之间的关联，对潜在混杂因素进行了调整并按性别分层。结果 母体全氟辛烷磺酸 (PFOS) 增加，全氟辛酸 (PFOA)、全氟壬酸 (PFNA)、全氟癸酸 (PFDA) 和全氟十一烷酸 (PFUnDA) 与较低的 BW、较低的胎龄 BW 和 SGA 出生有关。相关性仅在女孩中显着，与最低四分位数暴露的产前暴露相比，高四分位数的产前暴露与 93-142 克的低体重相关。这些关联不受对孕龄的影响。结论 我们发现产前暴露于五种不同的 PFAS 与出生体重之间存在关联，女孩的关联比男孩更明显。相关性仅在女孩中显着，与最低四分位数暴露的产前暴露相比，高四分位数的产前暴露与 93-142 克的低体重相关。这些关联不受对孕龄的影响。结论 我们发现产前暴露于五种不同的 PFAS 与出生体重之间存在关联，女孩的关联比男孩更明显。相关性仅在女孩中显着，与最低四分位数暴露的产前暴露相比，高四分位数的产前暴露与 93-142 克的低体重相关。这些关联不受对孕龄的影响。结论 我们发现产前暴露于五种不同的 PFAS 与出生体重之间存在关联，女孩的关联比男孩更明显。