The neuroendocrine system can be modulated by a magnetic field and cerebral ischemia as external and internal stressors, respectively. This study deals with the separate or combined effects of an extremely low frequency (ELF) magnetic field (50 Hz, average magnetic field of 0.5 mT) for 7 days and global cerebral ischemia for 10 min on the morpho-functional features of pituitary adrenocorticotrophic (ACTH) and thyrotrophic (TSH) cells in 3-month-old gerbils. To determine the immediate and delayed effects of the applied stressors, measurements were made on the 7th and 14th days after the onset of the experiment. The ELF magnetic field and 10-min global cerebral ischemia, separately and particularly in combination, decreased (P < 0.05) the volume density of ACTH cells, while only in combination were intracellular ACTH content and plasma ACTH concentration increased (P < 0.05) on day 7. The ELF magnetic field elevated serum TSH concentration on day 7 and intracellular TSHβ content on day 14 (P < 0.05). Also, 10-min global cerebral ischemia alone increased serum TSH concentration (P < 0.05), while in combination with the ELF magnetic field it elevated (P < 0.05) intracellular TSHβ content on day 14. In conclusion, an ELF magnetic field and/or 10-min global cerebral ischemia can induce immediate and delayed stimulation of ACTH and TSH synthesis and secretion. Bioelectromagnetics. 2020;41:91-103. © 2019 Bioelectromagnetics Society.

中文翻译：

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极低频磁场和全脑缺血会影响沙鼠的垂体ACTH和TSH细胞。

神经内分泌系统可以分别作为外部和内部应激源通过磁场和脑缺血进行调节。这项研究涉及7天的极低频（ELF）磁场（50 Hz，平均磁场为0.5 mT）和10分钟的整体脑缺血对垂体肾上腺皮质营养（ 3个月大的沙鼠中的促肾上腺皮质激素（ACTH）和促甲状腺激素（TSH）细胞。为了确定所施加压力的即时和延迟影响，在实验开始后的第7天和第14天进行测量。ELF磁场和10分钟的整体性脑缺血分别（特别是组合）降低了ACTH细胞的体积密度（P <0.05），在第7天，仅细胞内ACTH含量增加，血浆ACTH浓度增加（P <0.05）。ELF磁场在第7天升高血清TSH浓度，在第14天升高细胞内TSHβ含量（P <0.05）。同样，仅10分钟的整体性脑缺血会增加血清TSH浓度（P <0.05），而与ELF磁场组合会在第14天升高细胞内TSHβ含量（P <0.05）。总之，ELF磁场和/或10分钟的整体性脑缺血可引起ACTH和TSH合成和分泌的立即和延迟刺激。生物电磁学。2020; 41：91-103。©2019生物电磁学会。仅第10分钟的整体性脑缺血会增加血清TSH浓度（P <0.05），而与ELF磁场组合会在第14天升高细胞内TSHβ含量（P <0.05）。总之，ELF磁场和/或10 -min的整体性脑缺血可诱导ACTH和TSH合成和分泌的立即和延迟刺激。生物电磁学。2020; 41：91-103。©2019生物电磁学会。仅第10分钟的整体性脑缺血会增加血清TSH浓度（P <0.05），而与ELF磁场组合会在第14天升高细胞内TSHβ含量（P <0.05）。总之，ELF磁场和/或10 -min的整体性脑缺血可诱导ACTH和TSH合成和分泌的立即和延迟刺激。生物电磁学。2020; 41：91-103。©2019生物电磁学会。