A copper-catalyzed tandem process to generate chiral cyclobutene derivatives has been developed. It is based on an enantioselective conjugate addition or reduction of a cyclobutenone and sequential trapping with a chlorophosphate in a one-pot process. These phosphates are stable under mildly acidic conditions and serve as good electrophiles in Negishi coupling reactions.

中文翻译：

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通过催化共轭加成/俘获策略对3-取代的环戊二烯进行对映选择性合成。

已经开发了铜催化的串联方法以产生手性环丁烯衍生物。它基于一锅法中环丁烯酮的对映选择性共轭添加或还原，以及用氯磷酸盐顺序捕集。这些磷酸盐在弱酸性条件下稳定，在Negishi偶联反应中可作为良好的亲电子试剂。