Pulmonary hypertension (PH) is a diverse collection of vascular disorders that cause remodelling of small pulmonary arteries, resulting in increases in pulmonary vascular resistance and pulmonary arterial pressure. The World Health Organization classifies these disorders into five groups. Group III includes pulmonary hypertension associated with hypoxic lung disorders such as COPD. While not everyone with COPD develops pulmonary hypertension, those who do are more likely to experience acute exacerbations, hospitalisations, and poorer outcomes. Because alveolar hypoxia is a key element driving this response, investigators have studied how chronic hypoxia contributes to the development of PH. HIF1 and HIF2 can play complementary, opposing or unrelated roles in mediating the response to low oxygen levels in different cell types. This study shows HIF2 plays a dominant role in mediating the development of PH in response to environmental hypoxia. http://bit.ly/2Cy46sR

中文翻译：

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HIF1 和 HIF2 在肺动脉高压中的作用：这一切都取决于背景

肺动脉高压 (PH) 是多种血管疾病的集合，可导致小肺动脉重塑，导致肺血管阻力和肺动脉压力增加。世界卫生组织将这些疾病分为五组。第 III 组包括与缺氧性肺病如 COPD 相关的肺动脉高压。虽然并非所有 COPD 患者都会发生肺动脉高压，但那些发生肺动脉高压的患者更有可能出现急性加重、住院和更差的结果。由于肺泡缺氧是驱动这种反应的关键因素，研究人员研究了慢性缺氧如何促进 PH 的发展。HIF1 和 HIF2 在介导不同细胞类型对低氧水平的反应中可以发挥互补、相反或不相关的作用。该研究表明 HIF2 在介导 PH 响应环境缺氧的发展中起主导作用。http://bit.ly/2Cy46sR