Pressed degreased walnut meal (WM) was prepared from walnut kernel by cold-press deoil. It was rich in polyphenols with high activities of lowering lipids, antioxidation, anti-inflammation, and others, but the hypoglycemic activity has scarcely been reported. The purpose of this research was to investigate the preventive effect of the extracts of WM (WMP) on T2DM rats and the regulation of WMP on intestinal flora. Some results showed that WMP significantly held FBG, FINS and GSP, OGTT, the serum and hepatic TG, TC, HDL-C, LDL-C, AST, ALT, LPS, TNF-α, IL-6, and the hepatic MDA, CAT, SOD, as well as, prevented the pathological damage of the liver and the pancreas. The results of 16SrDNA sequencing demonstrated that WMP impeded the changes of intestinal flora in feces, mainly including Firmicutes, Bacteroidetes, and Proteobacteria. These indicated that WMP had promising effects on T2DM, which could be associated with the modulation of gut bacteria.

由核桃仁经冷压脱油制备压制的脱脂核桃粉（WM）。它富含多酚，具有降低脂质，抗氧化，抗发炎等活性，但几乎没有降糖活性的报道。这项研究的目的是调查WM（WMP）提取物对T2DM大鼠的预防作用以及WMP对肠道菌群的调控。一些结果表明，WMP可显着保留FBG，FINS和GSP，OGTT，血清和肝TG，TC，HDL-C，LDL-C，AST，ALT，LPS，TNF-α，IL-6和肝MDA， CAT，SOD以及防止肝脏和胰腺的病理损伤。16SrDNA测序结果表明，WMP阻碍了粪便中肠道菌群的变化，主要包括硬毛菌，拟杆菌属和变形杆菌。