The article herein briefly introduces the story of the birth of click chemistry and its evolution after that. A new angle to interpret click reactions was proposed using the “reactivity‐availability‐functionality” trilogy. CuAAC (Copper‐catalyzed azide‐alkyne cycloaddition), the most popular click reaction by far, was revisited along with the thiol‐ene, metal‐free AAC, SuFEx (Sulfur(VI) fluoride exchange) and the lately discovered diazotransfer process. By encountering more and more near‐perfect reactions, click chemistry is evolving and expanding on the fringe of the chemistry and different scientific disciplines, destination unknown.

中文翻译：

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单击化学：在边缘发展

本文中的文章简要介绍了点击化学的诞生及其之后的发展过程。使用“反应性，可用性，功能性”三部曲，提出了一种新的角度来解释点击反应。迄今为止，最流行的点击反应是CuAAC（铜催化的叠氮化物-炔烃环加成反应），以及硫醇，无金属的AAC，SuFEx（氟化硫（VI）交换）和最近发现的重氮转移过程。通过遇到越来越多的近乎完美的反应，点击化学正在化学和不同科学学科（目的地未知）的边缘发展和扩展。