Here, we explore the manipulation of immune cell metabolism as a strategy in target discovery and drug development for immune-mediated diseases. Comparing exploitation of metabolic pathways to kill tumor cells for cancer treatment with the reprogramming of immune cells to treat autoimmune diseases highlights differences that confer several advantages to the latter (including a more favorable therapeutic index and greater target stability). We discuss technological capabilities and gaps, including the challenge of relating in vitro observations to in vivo biology. Finally, we conclude by identifying future opportunities that will move the field forward and accelerate drug discovery.

中文翻译：

---

免疫代谢的机遇与挑战：药物发现的新范例。

在这里，我们探索免疫细胞代谢的操纵，作为针对免疫介导疾病的靶标发现和药物开发中的一种策略。将代谢途径杀死肿瘤细胞以治疗癌症与免疫细胞重编程以治疗自身免疫性疾病的方法进行比较，突出显示了差异，后者赋予后者多种优势（包括更有利的治疗指数和更大的靶标稳定性）。我们讨论了技术能力和差距，包括将体外观察与体内生物学联系起来的挑战。最后，我们通过确定未来的机会来总结，这些机会将推动该领域的发展并加速药物发现。