The chiral recognition of organic compounds is of vital importance in the field of pharmacology and medicine. Unfortunately, the common analytical routes used in this field are significantly restricted by time spent and equipment demands. In this work, we propose an unprecedented alternative, aimed at enantiomer discrimination and estimation of their concentrations in an uncomplicated and instantaneous manner. The proposed approach is based on the creation of an optical fiber probe with two pronounced plasmonic bands attributed to gold and silver. The gold or silver surfaces were grafted with moieties, able to enunciating entrap chiral amines from solution, resulting in a wavelength shift corresponding to each plasmonic metal. As a model compound of chiral amine, we chose the DOPA, also taking in mind its high medical relevancy. For chiral detection, the optical fiber probe was simply immersed in an analytical solution of DOPA, and the selective shift of gold or silver plasmon bands was observed in the reflected light depending on DOPA chirality. The observed shifts depend on the concentration of DOPA enantiomers. In the case of a racemic mixture, the shifts of both plasmonic bands emerge, making possible the simultaneous determination of enantiomer concentrations and their ratio. The analytical cycle takes several minutes and requires very simple laboratory equipment.

中文翻译：

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单等离子活性光纤探针，用于瞬时手性检测。

有机化合物的手性识别在药理学和医学领域至关重要。不幸的是，在该领域中使用的通用分析路线受到所花费的时间和设备需求的极大限制。在这项工作中，我们提出了一种空前的替代方法，旨在以一种不复杂且即时的方式对映体进行区分和估计其浓度。所提出的方法基于具有两个明显归因于金和银的等离激元能带的光纤探针的创建。金或银表面已接枝了部分，能够从溶液中阐明包封的手性胺，从而导致与每种等离激元金属相对应的波长偏移。作为手性胺的模型化合物，我们在选择DOPA的同时还考虑了其​​与医学的高度相关性。对于手性检测，只需将光纤探头浸入DOPA的分析溶液中，即可根据DOPA手性在反射光中观察到金或银等离激元带的选择性移动。观察到的变化取决于DOPA对映异构体的浓度。在外消旋混合物的情况下，出现了两个等离激元带的移动，从而可以同时测定对映异构体浓度及其比例。分析周期需要几分钟，并且需要非常简单的实验室设备。两个等离激元带的移动都出现了，这使得同时测定对映异构体浓度及其比例成为可能。分析周期需要几分钟，并且需要非常简单的实验室设备。两个等离激元带的移动都出现了，这使得同时测定对映异构体浓度及其比例成为可能。分析周期需要几分钟，并且需要非常简单的实验室设备。