The preparation of new RSV inhibitors required an efficient synthesis of (R)-2-methylazepane ((R)-1) amenable to large-scale production to support preclinical studies. After consideration of different options, an efficient five-step synthesis relying on the preparation of the racemic N-Boc precursor and its purification by chiral SFC was developed and successfully implemented on a 400 g scale.

中文翻译：

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目的合成（R）-2-甲基氮杂环庚烷

制备新的RSV抑制剂需要有效合成适合大规模生产的（R）-2-甲基氮杂环庚烷（（R）-1），以支持临床前研究。在考虑了不同的选择之后，开发了一种有效的五步合成方法，该方法依赖于外消旋N- Boc前体的制备及其通过手性SFC的纯化，并成功实现了400 g的规模。