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Neuromyelitis optica in patients with increased interferon alpha concentrations.
The Lancet Neurology ( IF 48.0 ) Pub Date : 2020-01-01 , DOI: 10.1016/s1474-4422(19)30445-4
Jac Williams 1 , Sarah McGlasson 2 , Sarosh Irani 3 , Darragh Duffy 4 , Yanick Crow 2 , David Hunt 5 ,
Affiliation  

Recombinant interferon alpha is used to treat several immunological, oncological, and infectious diseases, and various serious side-effects have been associated with its therapeutic use. We want to bring attention to the development of neuromyelitis optica spectrum disorder (NMOSD), a rare opticospinal neuroinflammatory disease associated with autoantibodies against the glial water channel aquaporin-4, following the clinical administration of recombinant interferon alpha therapies, and in other instances of increased interferon α (IFNα) concentrations.

中文翻译:

干扰素α浓度增加患者的视神经脊髓炎。

重组干扰素α用于治疗几种免疫学、肿瘤学和传染病,并且各种严重的副作用与其治疗用途有关。我们希望引起人们对视神经脊髓炎谱系障碍 (NMOSD) 的关注,这是一种罕见的视脊髓神经炎性疾病,与针对神经胶质水通道水通道蛋白 4 的自身抗体相关,在临床使用重组干扰素 α 疗法后,以及在其他情况下增加干扰素α(IFNα)浓度。
更新日期:2019-12-13
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