Agrochemicals represent a significant class of endocrine disrupting chemicals that humans and animals around the world are exposed to constantly. Agrochemicals can act as endocrine disrupting chemicals through a variety of mechanisms. Recent studies have shown that several mechanisms of action involve the ability of agrochemicals to mimic the interaction of endogenous hormones with nuclear receptors such as estrogen receptors, androgen receptors, peroxisome proliferator activated receptors, the aryl hydrocarbon receptor, and thyroid hormone receptors. Further, studies indicate that agrochemicals can exert toxicity through non-nuclear receptor-mediated mechanisms of action. Such non-genomic mechanisms of action include interference with peptide, steroid, or amino acid hormone response, synthesis and degradation as well as epigenetic changes (DNA methylation and histone modifications). This review summarizes the major mechanisms of action by which agrochemicals target the endocrine system.

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农用化学品的作用机理是破坏内分泌的化学品。

农用化学物质是一类重要的内分泌干扰化学物质，世界各地的人类和动物都经常接触这些化学物质。农用化学品可通过多种机制充当破坏内分泌的化学品。最近的研究表明，几种作用机理涉及农用化学品模拟内源激素与核受体（如雌激素受体，雄激素受体，过氧化物酶体增殖物激活受体，芳基烃受体和甲状腺激素受体）相互作用的能力。此外，研究表明，农用化学品可通过非核受体介导的作用机制发挥毒性作用。这种非基因组的作用机制包括干扰肽，类固醇或氨基酸激素反应，合成和降解以及表观遗传变化（DNA甲基化和组蛋白修饰）。这篇综述总结了农药作用于内分泌系统的主要作用机理。