Alzheimer’s disease (AD) is a complex neurological disorder with contributions from genetic and environmental factors. High‐resolution metabolomics (HRM) has the potential to identify novel endogenous and environmental factors involved in AD. Previous metabolomics studies have identified circulating metabolites linked to AD, but lack of replication and inconsistent diagnostic algorithms have hindered the generalizability of these findings. Here we applied HRM to identify plasma metabolic and environmental factors associated with AD in two study samples, with cerebrospinal fluid (CSF) biomarkers of AD incorporated to achieve high diagnostic accuracy.

中文翻译：

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血浆阿尔茨海默氏病的高分辨率代谢组学分析。

阿尔茨海默氏病（AD）是一种复杂的神经系统疾病，由遗传和环境因素引起。高分辨率代谢组学（HRM）有潜力识别AD中涉及的新型内源性和环境因素。先前的代谢组学研究已经确定了与AD相关的循环代谢物，但是缺乏复制和不一致的诊断算法阻碍了这些发现的普遍性。在这里，我们应用HRM在两个研究样本中鉴定与AD相关的血浆代谢和环境因素，并结合了AD的脑脊液（CSF）生物标记物以实现较高的诊断准确性。