Background & Objectives: Inconsistent data are available about the effect of curcumin supplementation on body weight. This systematic review and meta-analysis was done to summarize data from available clinical trials on the effect of curcumin supplementation on body weight, Body Mass Index (BMI), and Waist Circumference (WC).

Methods: PubMed, SCOPUS, Cochrane Library and Google Scholar were searched to find relevant articles up to August 2018. The effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Between-study heterogeneity was assessed using I². Subgroup analysis was done to find possible sources of heterogeneity.

Results: Totally, 11 studies that enrolled 876 subjects (53% women) were included. Combining effect sizes suggested a significant effect of curcumin administration on body weight (Weighed Mean Difference (WMD): −1.14 kg, 95% CI: −2.16, −0.12, P = 0.02) and BMI (WMD: −0.48 kg/m², 95% CI: −0.78, −0.17, P = 0.002), respectively. However, no significant effect of curcumin supplementation on WC was found (WMD: −1.51 cm, 95% CI: −4.041, 1.003, P = 0.23). Based on subgroup analysis, we found that the effect of curcumin on WC was significant in studies that prescribed ≥1000 mg/d curcumin (P ≤ 0.001), those with the intervention duration of ≥8 weeks (P ≤ 0.001), and those that was performed on overweight subjects (P ≤ 0.001).

Conclusions: We found a significant effect of curcumin supplementation on body weight and BMI, but not on WC. However, the effect of curcumin on WC was significant in studies done on overweight subjects, used ≥1000 mg/d curcumin, and ≥8 weeks of duration.

背景与目的：关于姜黄素补充剂对体重影响的数据不一致。进行了这项系统的综述和荟萃分析，总结了姜黄素补充剂对体重，体重指数（BMI）和腰围（WC）的影响的现有临床试验数据。

方法：搜索PubMed，SCOPUS，Cochrane Library和Google Scholar直至2018年8月的相关文章。效应大小以加权均数差（WMD）和95％置信区间（CI）表示。使用I ²评估研究之间的异质性。进行了亚组分析以发现异质性的可能来源。

结果：总共纳入11项研究，纳入876名受试者（53％为女性）。综合效应大小表明，姜黄素给药对体重（体重平均差异（WMD）：-1.14  kg，95％CI：-2.16，-0.12，P  = 0.02）和BMI（WMD：-0.48 kg / m ^{2）有显着影响}，95％CI：-0.78，-0.17，P  = 0.002）。但是，未发现姜黄素补充剂对WC有明显影响（WMD：-1.51 cm，95％CI：-4.041，1.003，P  = 0.23）。根据亚组分析，我们发现姜黄素对WC的影响在处方≥1000mg / d姜黄素的研究中具有显着意义（P ≤0.001），那些与已对超重受试者（执行≥8周（P≤0.01），而这些干预的持续时间P  ≤0.001）。

结论：我们发现补充姜黄素对体重和BMI有显着影响，但对WC没有影响。但是，姜黄素对WC的影响在对超重受试者进行的研究中非常重要，使用≥1000mg / d姜黄素且持续时间≥8周。