AIM To investigate clinical efficacy of transjugular intrahepatic portal shunt (TIPS) for the treatment of cirrhotic portal hypertension. METHODS 71 cases of patients with cirrhotic portal hypertension and esophageal and gastric variceal bleeding hospitalized from January 2014 to June 2017 were enrolled and treated with TIPS. The change of portal pressure and serum biochemical indexes before and after TIPS were compared, and re-hemorrhage rate, ascites incidence, complications, and survival rate were calculated. RESULTS 71 patients (male/female 47/24, aged 29-77 years, average 48.9 ± 9.8 years) with cirrhotic portal hypertension received TIPS. The success rate of TIPS was 93% (66/71). During 1-24 months (mean 12.5 ± 7 months) follow-up of 66 patients, 61 cases survived and 5 cases died. The portal pressure decreased significantly from 40.48 ± 3.15 cmH2O to 23.59 ± 4.41 cmH2O after TIPS (P < 0.05). During the follow-up, the incidence of hepatic encephalopathy was 12.1%, the incidence of re-hemorrhage was 18.2%, and there were 4 cases of stent dysfunction, with 1 case of bare stent and 3 cases of dual stent. CONCLUSION TIPS is an effective procedure for the treatment of cirrhotic portal hypertension complications, since it can reduce portal pressure and significantly alleviate ascites. Liver function is impaired in short-term after TIPS, but TIPS has no significant effect on liver function in middle-term.

中文翻译：

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经颈静脉肝内门分流术治疗肝硬化引起的门静脉高压症：单中心经验。

目的探讨经颈静脉肝内门静脉分流术（TIPS）治疗肝硬化门脉高压症的临床疗效。方法纳入2014年1月至2017年6月住院的71例肝硬化门脉高压并合并食管和胃静脉曲张破裂出血的患者，并进行TIPS治疗。比较TIPS前后门脉压力和血清生化指标的变化，计算再次出血率，腹水发生率，并发症和生存率。结果71例肝硬化门静脉高压症患者（男/女47/24，年龄29-77岁，平均48.9±9.8岁）接受了TIPS。TIPS的成功率为93％（66/71）。在1至24个月（平均12.5±7个月）的随访中，有66例患者存活，其中61例存活，5例死亡。门脉压力从40.48±3显着降低。TIPS后为15 cmH2O至23.59±4.41 cmH2O（P <0.05）。随访期间，肝性脑病的发生率为12.1％，再次出血的发生率为18.2％，其中支架功能障碍4例，裸支架1例，双支架3例。结论TIPS是治疗肝硬化门脉高压并发症的有效方法，因为它可以降低门脉压力并显着减轻腹水。TIPS后短期内肝功能受损，但中期TIPS对肝功能无明显影响。结论TIPS是治疗肝硬化门脉高压并发症的有效方法，因为它可以降低门脉压力并显着减轻腹水。TIPS后短期内肝功能受损，但中期TIPS对肝功能无明显影响。结论TIPS是治疗肝硬化门脉高压并发症的有效方法，因为它可以降低门脉压力并显着减轻腹水。TIPS后短期内肝功能受损，但中期TIPS对肝功能无明显影响。