BACKGROUND This study reports findings in subjects who underwent brain imaging for any reason, and examined factors influencing cerebrovascular events (CVEs) in hemodialysis (HD) patients. METHODS We reviewed the files of patients on HD between January 2015 and January 2018. A total of 432 patients who underwent HD for at least 5 months by the January 2015 and who were older than 18 years were included in the study; 264 had been examined by cerebral computed tomography or magnetic resonance imaging examination within the 3 years. Cerebrovascular pathology was detected in 139 of 264 patients. RESULTS Of the 139 patients, 65 (24.62%) had ischemic lesions, 25 (9.47%) had hemorrhagic lesions, and 49 (18.56%) had cerebral small vessel disease (CSVD). We compared recorded data and later clinical findings between patients with and those without CVEs. The cause of end-stage renal disease was diabetes in 58.5% of patients with ischemic lesions, 52% in those with hemorrhagic lesions, and 55% in those with CSVD (P < 0.05). Patients with cerebrovascular ischemia were older (P = 0.0001) and had lower serum creatinine (sCr) (P = 0.0001) and higher serum C-reactive protein (CRP) (P = 0.002) levels than normal subjects. Hemorrhagic patients were older (P = 0.003) and had lower sCr (P = 0.003) and serum predialysis potassium (P = 0.003) and parathyroid hormone (PTH) (P = 0.004) levels than normal subjects. Patients with CSVD were older (P < 0.0001) and had lower sCr (P < 0.0001), phosphorus (P < 0.007), and PTH (P < 0.013) and higher CRP (P < 0.002) levels than normal subjects. CONCLUSIONS HD patients with CVEs are older and typically have diabetes mellitus and lower sCr levels.

中文翻译：

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血液透析患者的脑血管事件；回顾性观察研究。

背景技术本研究报告了因任何原因进行了脑部成像的受试者的发现，并检查了影响血液透析（HD）患者脑血管事件（CVE）的因素。方法我们回顾了2015年1月至2018年1月HD患者的档案。研究共纳入432位在2015年1月之前接受HD至少5个月且年龄大于18岁的患者。在这3年中，通过脑计算机断层扫描或磁共振成像检查检查了264例。在264例患者中有139例检测到脑血管病理。结果139例患者中，有65例（占24.62％）有缺血性病变，有25例（占9.47％）有出血性病变，有49例（18.56％）有脑小血管疾病（CSVD）。我们比较了有和没有CVE的患者之间的记录数据和以后的临床发现。终末期肾脏疾病的原因是缺血性病变患者中的糖尿病占58.5％，出血性病变患者中占52％，CSVD患者中占55％（P <0.05）。脑血管缺血患者比正常人年龄更大（P = 0.0001），血清肌酐（sCr）（P = 0.0001）和血清C反应蛋白（CRP）水平较高（P = 0.002）。出血患者比正常人年龄更大（P = 0.003），sCr（P = 0.003）和血清透析前钾（P = 0.003）和甲状旁腺激素（PTH）（P = 0.004）较低。CSVD患者比正常人年龄更大（P <0.0001），sCr（P <0.0001），磷（P <0.007）和PTH（P <0.013）和CRP（P <0.002）水平较低。结论HD的CVE患者年龄较大，通常患有糖尿病且sCr水平较低。