Long‐term and stable fixation of implants is one of the most important points for a successful orthopedic surgery in the field of endoprosthesis. Osseointegration (OI), functional connection between bone and implants, is considered as a pivotal process of cementless implant fixation and integration, respectively. OI is affected by various factors of which the property of implants is of high significance. The modification of implants surface for better OI has raised increasing attention in modern orthopedic medicine. Here, the process of OI and the interactions between implants and ambient bone tissues were emblazed. The knowledge regarding the contemporary surface modification strategies was systematically analyzed and reviewed, including materials used for the fabrication of implants, advanced modification techniques, and key factors in the design of porous implants structure. We discussed the superiority of current surface modification programs and concluded that the problems remain to be solved. The primary intention of this systematic review is to provide comprehensive reference information and an extensive overview for better fabrication and design of orthopedic implants.

中文翻译：

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种植体表面修饰在骨整合中的作用：系统评价。

植入物的长期稳定固定是内置假体领域骨科手术成功的最重要点之一。骨整合（OI）是骨和种植体之间的功能连接，被认为是非骨水泥种植体固定和整合的关键过程。OI受多种因素影响，其中植入物的特性具有重要意义。改善植入物表面以获得更好的 OI 在现代骨科医学中引起了越来越多的关注。在这里，OI 的过程以及植入物与周围骨组织之间的相互作用被点燃。系统地分析和审查了有关当代表面改性策略的知识，包括用于制造植入物的材料、先进的改性技术、以及多孔植入物结构设计的关键因素。我们讨论了当前表面改性程序的优越性，并得出结论，这些问题仍有待解决。本系统评价的主要目的是为更好地制造和设计骨科植入物提供全面的参考信息和广泛的概述。