当前位置: X-MOL 学术ChemNanoMat › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mitochondria‐Targeted Nanoscale MOFs for Improved Photodynamic Therapy
ChemNanoMat ( IF 3.8 ) Pub Date : 2019-10-14 , DOI: 10.1002/cnma.201900507
Ming Gong 1 , Jian Yang 1 , Qixin Zhuang 1 , Yongsheng Li 1 , Jinlou Gu 1
Affiliation  

Due to the existence of hypoxic microenvironment, the efficacy of photodynamic therapy (PDT) is frequently weakened. As a result, targeted treatment toward oxygen‐rich mitochondria is considered as a promising cancer therapy. Herein, both triphenylphosphine (TPP) and folic acid (FA) are simultaneously grafted onto nanoscale metal‐organic frameworks (NMOFs) to realize dual‐targeting delivery of the nanoplatforms into cancer cells and their mitochondria via the proposed phosphorylation modification strategy. A large amount of highly efficient photosensitizer of porphyrinic molecules is integrated into the NMOFs with a uniform particle size of about 65 nm. Thanks to the strong Zr−O−P bonding, a dense coverage of phosphonate‐conjugating targeting molecules on NMOFs is obtained and each surficial unsaturated Zr−O cluster is adequately occupied. The resultant dual‐targeting NMOFs feature high biostability and biocompatibility, as well as improved cellular uptake and mitochondrial accumulation. The PDT efficacy of these dual‐targeting NMOFs is significantly improved with a low IC50 of 0.74 μM upon 10 min light radiation, which is at least four times higher than that of non‐targeting counterparts. This phosphorylation strategy would be hopeful for immobilizing a variety of biogenic groups on NMOFs to make them targetable to various specific organelles and to improve the therapy efficacy on related diseases.

中文翻译:

线粒体靶向纳米MOF改善光动力疗法

由于缺氧的微环境的存在,光动力疗法(PDT)的功效经常被削弱。结果,针对富氧线粒体的靶向治疗被认为是一种有前途的癌症治疗方法。本文将三苯基膦(TPP)和叶酸(FA)同时移植到纳米级金属有机框架(NMOF)上,以通过拟议的磷酸化修饰策略实现将纳米平台双目标递送至癌细胞及其线粒体中。大量的卟啉分子的高效光敏剂被整合到NMOF中,其均匀粒径约为65 nm。多亏了强大的Zr-O-P键,NMOFs上的膦酸酯共轭靶向分子得到了密集的覆盖,每个表面的不饱和Zr-O簇都被充分占据。由此产生的双重靶向NMOF具有很高的生物稳定性和生物相容性,并改善了细胞摄取和线粒体积累。这些双重目标NMOF的PDT功效通过较低的IC得以显着提高在10分钟的光照射下,有50个(0.74μM),至少是非目标对应物的四倍。这种磷酸化策略对于将多种生物基团固定在NMOF上具有希望,使其可靶向各种特定细胞器并提高对相关疾病的治疗效果。
更新日期:2019-10-14
down
wechat
bug