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Perinatal programming of metabolic diseases: The role of glucocorticoids.
Metabolism ( IF 9.8 ) Pub Date : 2019-12-11 , DOI: 10.1016/j.metabol.2019.154047
Júlia Cristina Facchi 1 , Thalyne Aparecida Leite de Lima 1 , Lucas Ryba de Oliveira 1 , Hercules de Oliveira Costermani 1 , Ginislene Dias Souza Miranda 1 , Júlio Cezar de Oliveira 1
Affiliation  

The worldwide increase in metabolic diseases has urged the scientific community to improve our understanding about the mechanisms underlying its cause and effects. A well supported area of studies had related maternal stress with early programming to the later metabolic diseases. Mechanisms upon origins of metabolic disturbances are not yet fully understood, even though stressful factors rising glucocorticoids have been put out as pivotal trigger by programming metabolic diseases as long-term consequence. Considering energy balance and glucose homeostasis, by producing and/or sensing regulator signals, hypothalamus-pituitary-adrenal axis and endocrine pancreas are directly affected by glucocorticoids excess. We focus on the evidences reporting the role of increased glucocorticoids due to perinatal insults on the physiological systems involved in the metabolic homeostasis and in the target organs such as endocrine pancreas, white adipose tissue and blood vessels. Besides, we review some mechanisms underlining the malprogramming of type 2 diabetes, obesity and hypertension. Studies on this field are currently ongoing and even there is a good understanding regarding the effects of glucocorticoids addressing metabolic diseases, few is known about the relationship between maternal insults rising glucocorticoids to pups' metabolic disturbances, a thorough understanding about that may provide pivotal clinical clues regarding those disorders.

中文翻译:

代谢性疾病的围产期编程:糖皮质激素的作用。

全球范围内新陈代谢性疾病的增加促使科学界加深了对其成因和作用机理的理解。一项得到充分支持的研究领域将母亲的压力与早期的编程与后来的代谢性疾病相关。尽管通过将代谢性疾病编程为长期后果,已将引起糖皮质激素升高的压力因素作为关键触发因素,但对代谢紊乱起源的机制仍未完全了解。考虑到能量平衡和葡萄糖稳态,通过产生和/或感知调节信号,下丘脑-垂体-肾上腺轴和内分泌胰腺直接受到糖皮质激素过量的影响。我们关注于证据,这些证据报告了围产期侮辱对参与代谢动态平衡和靶器官(例如内分泌胰腺,白色脂肪组织和血管)的生理系统造成的糖皮质激素增加的作用。此外,我们回顾了一些机制,这些机制强调了2型糖尿病,肥胖症和高血压的编程错误。该领域的研究目前仍在进行中,即使对糖皮质激素治疗代谢疾病的效果已有很好的了解,对孕产妇不断增加的糖皮质激素与幼崽代谢紊乱之间的关系知之甚少,对此的透彻了解可能会提供关键的临床线索。关于那些疾病。白色脂肪组织和血管。此外,我们回顾了一些机制,这些机制强调了2型糖尿病,肥胖症和高血压的编程错误。该领域的研究目前仍在进行中,即使对糖皮质激素对代谢疾病的影响有很好的了解,对母体侮辱性糖皮质激素升高与幼鼠的代谢紊乱之间的关系知之甚少,对此的透彻了解可能会提供关键的临床线索。关于那些疾病。白色脂肪组织和血管。此外,我们回顾了一些机制,这些机制突显了2型糖尿病,肥胖症和高血压的编程错误。该领域的研究目前仍在进行中,即使对糖皮质激素治疗代谢疾病的效果已有很好的了解,对孕产妇不断增加的糖皮质激素与幼崽代谢紊乱之间的关系知之甚少,对此的透彻了解可能会提供关键的临床线索。关于那些疾病。
更新日期:2019-12-11
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