This study demonstrates a novel, facile and one-pot approach to synthesize silica nanoparticles with silver at core and crust (SiNP-AgCC). A modified Stöber method was used to make SiNP-AgCC. A significant reduction in the size of SiO₂ nanoparticles was seen, with 2–5 nm AgNPs being uniformly distributed on the surface and 10–20 nm AgNPs in the center. A typical mesoporous SiO₂ particle (SiNP) produced using the Stöber method was transformed to nanoporous SiO₂ by this modified Stöber method. Nanoporous SiO₂ particles with silver in the center are advantageous for slow and consistent Ag⁺ release, which was confirmed by Ag⁺ ion release test. Antibacterial activities of the samples were tested to evaluate the disinfection performance of the samples on gram-negative bacteria (Escherichia coli) using disk diffusion and the LB-agar method. SiNP-AgCC showed prolonged silver release for more than 20 days and improved antibacterial properties even after five days of incubation.

这项研究证明了一种新颖，简便，一锅法的方法，可以合成在芯和壳上带有银的二氧化硅纳米粒子（SiNP-AgCC）。改良的Stöber方法用于制备SiNP-AgCC。观察到SiO ₂纳米粒子的尺寸显着减小，其中2–5 nm AgNPs均匀分布在表面，而10–20 nm AgNPs在中心。通过这种改良的斯托伯方法，将使用斯托伯方法生产的典型介孔SiO ₂颗粒（SiNP）转变为纳米多孔SiO ₂。中心具有银的纳米多孔SiO ₂颗粒有利于缓慢且稳定地释放Ag ⁺，这一点已由Ag ⁺证实。离子释放测试。使用圆盘扩散法和LB-琼脂法对样品的抗菌活性进行了测试，以评估样品对革兰氏阴性细菌（大肠杆菌）的消毒性能。SiNP-AgCC甚至在孵育五天后仍显示出更长的银释放时间超过20天，并改善了抗菌性能。