Blood stream infections in the cancer patients are a critical problem which leads to considerable rate of mortality and morbidity. In view of this herein, we account the response of Poly Vinyl Pyrrolidone (PVP) coated silver nanowires (Ag-NWs) and silver nano cubes (Ag-NCs) towards carbapenem (Escherichia coli) and vancomycin (Staphylococcus aureus) resistant strains as well as to human epithelial cells. The prepared PVP capped silver nanomaterials were in the range of 80 nm (Ag-NC) and 25 nm (Ag-NW) as observed from Transmission Electron Microscopy (TEM). Though the selected strains were resistant to carbapenem and vancomycin, PVP capped Ag-NWs and Ag-NCs could inhibit the growth of these strains. These nanomaterials could break the cell wall and damage the genetic material of these strains as observed by death rate assay and alkaline comet assay. Furthermore, we have shown that toxicity of Ag-NWs and Ag-NCs precisely follows the dose retort pattern. Even though the resistant strains were susceptible to a concentration of 10 µg ml⁻¹ of silver nanomaterials the epithelial cells were not affected by the same concentration. It is also confirmed with live dead staining assay and observed that metabolic activities of epithelial cells were not affected by a concentration of 10 µg ml⁻¹. Overall, this work suggests that these nanomaterials can be utilized to treat the multiple drug resistant strains from cancer patients.

癌症患者中的血流感染是关键问题，其导致相当高的死亡率和发病率。鉴于此，我们考虑了涂覆聚乙烯吡咯烷酮（PVP）的银纳米线（Ag-NWs）和银纳米立方体（Ag-NCs）对碳青霉烯（大肠杆菌）和万古霉素（金黄色葡萄球菌）的响应耐药株以及人类上皮细胞。从透射电子显微镜（TEM）观察，制备的PVP覆盖的银纳米材料在80nm（Ag-NC）和25nm（Ag-NW）的范围内。尽管选定的菌株对碳青霉烯和万古霉素具有抗性，但用PVP封端的Ag-NW和Ag-NCs可以抑制这些菌株的生长。如通过死亡率测定和碱彗星测定所观察到的那样，这些纳米材料可能破坏细胞壁并破坏这些菌株的遗传物质。此外，我们已经表明，Ag-NWs和Ag-NCs的毒性正好遵循剂量re模式。即使耐药菌株对10 µg ml ^-1的浓度敏感银纳米材料的上皮细胞不受相同浓度的影响。还通过活死染色测定法证实，并且观察到10μgml ^-1的浓度不影响上皮细胞的代谢活性。总的来说，这项工作表明这些纳米材料可用于治疗癌症患者的多种耐药菌株。