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The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine.
Pharmacology Biochemistry and Behavior ( IF 3.6 ) Pub Date : 2019-12-05 , DOI: 10.1016/j.pbb.2019.172836
Natalie Nardone 1 , Marian Shahid 2 , Andrew A Strasser 3 , Delia A Dempsey 4 , Neal L Benowitz 5
Affiliation  

Background

A faster rate of nicotine metabolism has been associated with smoking more cigarettes, greater nicotine withdrawal symptoms, and lower smoking quit rates. However, the association between nicotine metabolic rate (NMR) and cognitive functioning during withdrawal has not been determined.

Methods

We compared cognitive function in 121 fast or slow nicotine metabolizers after smoking, and at 3 and 6 h of nicotine abstinence. Cognitive functioning was assessed using N-back working memory tests with outcomes of accuracy and processing speed. Participants smoked two cigarettes and then abstained from smoking for 6 h. N-back tests were administered after smoking (0 h) and at 3 and 6 h of nicotine abstinence.

Results

An effect of processing speed was found over time on the 2-back, in that participants had significantly longer average reaction times when the stimuli presented did not match the target letter. NMR was not significantly associated with the processing speed change over time. Within-race differences in working memory were evident in that Caucasian fast metabolizers had significantly poorer accuracy and processing speed.

Conclusions

Minimal change in working memory over 6 h of nicotine abstinence was observed. Overall, NMR was not significantly associated with the change in processing speed, however Caucasian fast metabolizers displayed poorer accuracy and processing speed at discrete time points.



中文翻译:

戒断尼古丁 6 小时后尼古丁代谢率对工作记忆的影响。

背景

尼古丁代谢速​​度加快与吸烟量增加、尼古丁戒断症状加重以及戒烟率降低有关。然而,尼古丁代谢率(NMR)与戒断期间认知功能之间的关联尚未确定。

方法

我们比较了 121 名快速或慢速尼古丁代谢者吸烟后以及尼古丁戒断 3 小时和 6 小时时的认知功能。使用 N-back 工作记忆测试评估认知功能,结果包括准确性和处理速度。参与者吸了两支烟,然后戒烟 6 小时。在吸烟后(0 小时)以及戒除尼古丁 3 小时和 6 小时时进行 N-back 测试。

结果

随着时间的推移,处理速度对 2-back 产生了影响,因为当呈现的刺激与目标字母不匹配时,参与者的平均反应时间明显更长。NMR 与处理速度随时间的变化没有显着相关性。工作记忆的种族内差异很明显,因为白人快速代谢者的准确性和处理速度明显较差。

结论

戒断尼古丁 6 小时后,观察到工作记忆的变化极小。总体而言,NMR 与处理速度的变化没有显着相关,但白人快速代谢者在离散时间点表现出较差的准确性和处理速度。

更新日期:2019-12-05
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