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Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MSe.
Journal of Pharmaceutical Analysis ( IF 8.8 ) Pub Date : 2019-10-01 , DOI: 10.1016/j.jpha.2019.09.007
Kumar Katragunta 1, 2, 3 , Bandi Siva 1 , Niharika Kondepudi 1 , P R Rao Vadaparthi 1 , Nadendla Rama Rao 2 , Ashok Kumar Tiwari 1 , Katragadda Suresh Babu 1
Affiliation  

Boswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties. A chromatographic method was developed for the analysis and quantification of six boswellic acid marker compounds, i.e., keto boswellic acid (1), 3-O-Acetyl 11-keto β-boswellic acid (2), ɑ-Boswellic acid (3), β-Boswellic acid (4), 3-O-Acetyl-ɑ-boswellic acid (5) and 3-O-Acetyl-β-boswellic acid (6) in commercial herbal products containing B. serrata as an ingredient. Combining UPLC with Q-Tof-MS/MS makes the better identification of secondary metabolites and adulterants in the herbal formulations containing B. serrata in rapid time using fragmentation approach than the traditional approaches. In this study quantification of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia guidelines. Furthermore, minor phytochemical constituents were identified and characterized with the help of LC-Q-Tof-MS/MS fragmentation data and various isoforms of boswellic acids and tirucallic acids in B. serrata oleo-gum-resin extract were identified.



中文翻译:

使用UPLC-Q-Tof-MSe对含有乳香锯齿提取物的草药配方中的乳香酸进行估算,并对次生代谢产物进行全面表征。

乳香乳香在印度医学体系中被广泛使用,并且以其潜在的药用特性而闻名。开发了一种色谱方法,用于分析和定量六种乳香酸标记化合物,即酮乳香酸(1),3-O-乙酰基11-酮基β-乳香酸(2),γ-乳香酸(3),含有锯缘芽孢杆菌作为成分的市售草药产品中的β-乳香酸(4),3-O-乙酰基-β-乳香酸(5)和3-O-乙酰基-β-乳香酸(6)。将UPLC与Q-Tof-MS / MS结合使用可更好地鉴定含有以下成分的草药配方中的次生代谢物和掺杂物锯齿状芽孢杆菌在快速时间内使用的是碎片化方法,而不是传统方法。在这项研究中,按照药典指南对采用UPLC-PDA方法的乳香酸进行了定量。此外,借助LC-Q-Tof-MS / MS碎片数据鉴定并鉴定了少量植物化学成分,并鉴定了锯缘肉芽孢杆菌油-口香糖树脂提取物中的乳香酸和丁香酸的各种同工型。

更新日期:2019-10-01
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