Healthcare is in the midst of a transformative shift from centralized care to point-of-care (POC). In this regard, recent efforts have focused on integration of biosensing technologies with clinical management and existing healthcare systems to improve the effectiveness and quality of care. Plasmonic technologies in particular, have been used for multiple applications in biosensing, pharmaceutical industry, food quality monitoring, and healthcare. However, bulky-sized platforms, expensive instrumentation, incomprehensive benchmarking, laborious protocols, and time-consuming processing steps remain challenges to adopt biosensing platforms to the POC settings. Here, we present a hand-held biosensing platform that integrates a plasmonic detection modality with a microfluidic chip. As a biological target model, we assess hemoglobin—an iron carrying protein in red blood cells. We comprehensively perform theoretical simulations and kinetic calculations to benchmark the platform performance. Overall, this miniaturized platform provides label-free detection, simple configuration for user-interface, facile sampling, assay-time down to 15–30 min, and inexpensive disposable chips. Therefore, this platform will potentially accelerate the deployment of portable biosensing systems for the POC and primary care settings.

医疗保健正处于从集中式医疗到即时医疗（POC）的转型之中。在这方面，最近的努力集中在将生物传感技术与临床管理和现有的医疗系统相集成，以提高护理的有效性和质量。尤其是等离子技术已在生物传感，制药行业，食品质量监测和医疗保健中得到了广泛的应用。但是，庞大的平台，昂贵的仪器，不全面的基准测试，费力的协议以及耗时的处理步骤仍然是将生物传感平台应用于POC设置的挑战。在这里，我们介绍了一个手持式生物传感平台，该平台将等离子体检测模式与微流控芯片集成在一起。作为生物学目标模型，我们评估了血红蛋白，一种在红细胞中携带铁的蛋白质。我们全面执行理论模拟和动力学计算，以基准测试平台性能。总体而言，这个小型平台可提供无标签检测，用户界面的简单配置，简便的采样，长达15-30分钟的测定时间以及廉价的一次性芯片。因此，该平台将有可能加速POC和基层医疗机构的便携式生物传感系统的部署。