The tumor microenvironment (TME) is an attractive target to develop novel strategies for hormone-dependent cancers. Several molecules in the TME can favor tumor development and progression, including lipoproteins. Lipoproteins are taken up by cancer cells, providing them with cholesterol and fatty acids. Cholesterol regulates cell signaling and it is converted into a series of bioactive metabolites, including hormones. The conflicting results of epidemiological and interventional studies suggest that the local availability of lipoproteins in the TME is more relevant for cancer biology than their circulating levels. Thus, reducing lipoprotein uptake and stimulating cell cholesterol efflux to high-density lipoproteins (HDLs) can represent a novel adjuvant strategy for cancer management. HDL-like particles can also act as drug delivery systems for tumor targeting.

中文翻译：

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脂蛋白在激素依赖性癌症微环境中的作用

肿瘤微环境 (TME) 是开发激素依赖性癌症新策略的一个有吸引力的目标。TME 中的几个分子可以有利于肿瘤的发展和进展，包括脂蛋白。脂蛋白被癌细胞吸收，为它们提供胆固醇和脂肪酸。胆固醇调节细胞信号，并转化为一系列生物活性代谢物，包括激素。流行病学和干预研究的相互矛盾的结果表明，TME 中脂蛋白的局部可用性与癌症生物学比其循环水平更相关。因此，减少脂蛋白摄取和刺激细胞胆固醇流出到高密度脂蛋白 (HDL) 可以代表一种新的癌症管理辅助策略。